| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 232 | 662 | 2.85 | 100 | 43.10% | 48 | 20.69% | 84 | 36.21% |
| 2021/22 | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Ajax | 26 | 20 | 3 | 3 | 77 | 11 | +66 | 63 | WWLW | 13 | 10 | 1 | 2 | 49 | 5 | 13 | 10 | 2 | 1 | 28 | 6 | ||
| 2 | PSV | 26 | 20 | 1 | 5 | 63 | 31 | +32 | 61 | WWWW | 13 | 10 | 0 | 3 | 35 | 18 | 13 | 10 | 1 | 2 | 28 | 13 | ||
| 3 | Feyenoord | 26 | 17 | 4 | 5 | 59 | 24 | +35 | 55 | WXLW | 13 | 9 | 2 | 2 | 32 | 12 | 13 | 8 | 2 | 3 | 27 | 12 | ||
| 4 | AZ | 26 | 16 | 3 | 7 | 50 | 30 | +20 | 51 | LWWW | 13 | 9 | 2 | 2 | 28 | 13 | 13 | 7 | 1 | 5 | 22 | 17 | ||
| 5 | FC Twente | 26 | 15 | 6 | 5 | 40 | 30 | +10 | 51 | WWWX | 12 | 7 | 4 | 1 | 18 | 8 | 14 | 8 | 2 | 4 | 22 | 22 | ||
| 6 | 1 | Vitesse | 25 | 12 | 5 | 8 | 32 | 38 | -6 | 41 | OWXL | 12 | 5 | 2 | 5 | 15 | 22 | 13 | 7 | 3 | 3 | 17 | 16 | |
| 7 | 1 | FC Utrecht | 26 | 11 | 7 | 8 | 43 | 33 | +10 | 40 | LXWX | 13 | 7 | 4 | 2 | 27 | 14 | 13 | 4 | 3 | 6 | 16 | 19 | |
| 8 | 2 | FC Groningen | 26 | 8 | 9 | 9 | 32 | 36 | -4 | 33 | WXWX | 13 | 4 | 6 | 3 | 14 | 12 | 13 | 4 | 3 | 6 | 18 | 24 | |
| 9 | 1 | Cambuur | 26 | 10 | 3 | 13 | 43 | 55 | -12 | 33 | LLWL | 13 | 5 | 1 | 7 | 25 | 29 | 13 | 5 | 2 | 6 | 18 | 26 | |
| 10 | 1 | NEC | 26 | 8 | 7 | 11 | 33 | 43 | -10 | 31 | LLLX | 12 | 2 | 4 | 6 | 12 | 18 | 14 | 6 | 3 | 5 | 21 | 25 | |
| 11 | 1 | Heracles Almelo | 26 | 7 | 6 | 13 | 27 | 35 | -8 | 27 | OLWL | 14 | 7 | 4 | 3 | 19 | 13 | 12 | 0 | 2 | 10 | 8 | 22 | |
| 12 | 1 | SC Heerenveen | 26 | 7 | 6 | 13 | 22 | 36 | -14 | 27 | OOLL | 13 | 3 | 2 | 8 | 12 | 21 | 13 | 4 | 4 | 5 | 10 | 15 | |
| 13 | 2 | Go Ahead Eagles | 26 | 7 | 6 | 13 | 27 | 43 | -16 | 27 | LXWX | 13 | 5 | 1 | 7 | 17 | 21 | 13 | 2 | 5 | 6 | 10 | 22 | |
| 14 | RKC Waalwijk | 26 | 5 | 9 | 12 | 28 | 42 | -14 | 24 | OLLX | 13 | 4 | 2 | 7 | 11 | 21 | 13 | 1 | 7 | 5 | 17 | 21 | ||
| 15 | Willem II | 26 | 6 | 4 | 16 | 21 | 44 | -23 | 22 | LOLL | 13 | 4 | 2 | 7 | 10 | 18 | 13 | 2 | 2 | 9 | 11 | 26 | ||
| 16 | 1 | Fortuna Sittard | 25 | 6 | 4 | 15 | 26 | 53 | -27 | 22 | WLLW | 12 | 4 | 2 | 6 | 14 | 24 | 13 | 2 | 2 | 9 | 12 | 29 | |
| 17 | 1 | Sparta | 24 | 4 | 8 | 12 | 19 | 37 | -18 | 20 | WLWL | 14 | 3 | 5 | 6 | 12 | 19 | 10 | 1 | 3 | 6 | 7 | 18 | |
| 18 | 2 | PEC Zwolle | 26 | 5 | 5 | 16 | 20 | 41 | -21 | 20 | LWLX | 13 | 2 | 4 | 7 | 9 | 15 | 13 | 3 | 1 | 9 | 11 | 26 | |
| 19 | +1 | Sébastien HALLER (Ajax, 1p) |
| 13 | Guus TIL (Feyenoord) | |
| Jesper KARLSSON (AZ, 4p) | ||
| 12 | Ricky VAN WOLFSWINKEL (FC Twente, 5p) | |
| 11 | Loïs OPENDA (Vitesse, 2p) | |
| Bryan LINSSEN (Feyenoord) | ||
| 10 | Vangelis PAVLIDIS (AZ) | |
| +1 | Jørgen LARSEN (FC Groningen) | |
| 9 | +1 | Dušan TADIĆ (Ajax, 2p) |
| Michiel KRAMER (RKC Waalwijk) | ||
| +1 | Luis SINISTERRA (Feyenoord) | |
| 8 | Henk VEERMAN (FC Utrecht, 2p) | |
| Cody GAKPO (PSV, 1p) | ||
| Jens ODGAARD (RKC Waalwijk) | ||
| IÑIGO CÓRDOBA Querejeta (Go Ahead Eagles) | ||
| Mats SEUNTJENS (Fortuna Sittard, 2p) | ||
| 7 | Bart RAMSELAAR (FC Utrecht, 1p) | |
| Dani DE WIT (AZ) | ||
| Nikolai BADEN FREDERIKSEN (Vitesse) | ||
| Luuk BROUWERS (Go Ahead Eagles, 1p) | ||
| Anastasios DOUVIKAS (FC Utrecht, 2p) | ||
| ANTONY Matheus (Ajax) | ||
| Cyril NGONGE (FC Groningen) | ||
| +1 | Eran ZEHAVI (PSV) |
| Friday, 11 March 2022 | |||||
| Cambuur | 2-3 | Ajax | |||
| 48 | Kallon | 3 | Tadić | ||
| 79 | Joosten | 40 | Haller | ||
| 90 | Gravenberch | ||||
| Saturday, 12 March 2022 | |||||
| Sparta | 1-0 | Go Ahead Eagles | |||
| 68 | Auassar | ||||
| FC Groningen | 4-3 | NEC | |||
| 2 | De Leeuw | 13 | Ali̇ | ||
| 22 | Larsen | 29 | Schøne | ||
| 80 | Postema | 32 | Mattsson | ||
| 90 | Postema | ||||
| RKC Waalwijk | 0-0 | SC Heerenveen | |||
| Sunday, 13 March 2022 | |||||
| FC Utrecht | 0-1 | PSV | |||
| 53 | Zehavi | ||||
| Fortuna Sittard | 1-0 | Willem II | |||
| 52 | Flemming | ||||
| AZ | 0-1 | FC Twente | |||
| 62 | Brenet | ||||
| Heracles Almelo | 0-0 | Vitesse | |||
| PEC Zwolle | 1-2 | Feyenoord | |||
| 45 | van Polen | 67 | Sinisterra | ||
| 77 | Dessers | ||||