| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 241 | 689 | 2.85 | 105 | 43.57% | 50 | 20.75% | 86 | 35.68% |
| 2021/22 | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Ajax | 27 | 21 | 3 | 3 | 80 | 13 | +67 | 66 | WWWL | 14 | 11 | 1 | 2 | 52 | 7 | 13 | 10 | 2 | 1 | 28 | 6 | ||
| 2 | PSV | 27 | 21 | 1 | 5 | 68 | 31 | +37 | 64 | WWWW | 14 | 11 | 0 | 3 | 40 | 18 | 13 | 10 | 1 | 2 | 28 | 13 | ||
| 3 | Feyenoord | 27 | 17 | 4 | 6 | 61 | 27 | +34 | 55 | LWXL | 13 | 9 | 2 | 2 | 32 | 12 | 14 | 8 | 2 | 4 | 29 | 15 | ||
| 4 | 1 | FC Twente | 27 | 16 | 6 | 5 | 41 | 30 | +11 | 54 | WWWW | 13 | 8 | 4 | 1 | 19 | 8 | 14 | 8 | 2 | 4 | 22 | 22 | |
| 5 | 1 | AZ | 27 | 16 | 4 | 7 | 52 | 32 | +20 | 52 | XLWW | 13 | 9 | 2 | 2 | 28 | 13 | 14 | 7 | 2 | 5 | 24 | 19 | |
| 6 | Vitesse | 26 | 12 | 5 | 9 | 33 | 40 | -7 | 41 | LOWX | 13 | 5 | 2 | 6 | 16 | 24 | 13 | 7 | 3 | 3 | 17 | 16 | ||
| 7 | FC Utrecht | 27 | 11 | 7 | 9 | 44 | 36 | +8 | 40 | LLXW | 14 | 7 | 4 | 3 | 28 | 17 | 13 | 4 | 3 | 6 | 16 | 19 | ||
| 8 | FC Groningen | 27 | 9 | 9 | 9 | 35 | 37 | -2 | 36 | WWXW | 13 | 4 | 6 | 3 | 14 | 12 | 14 | 5 | 3 | 6 | 21 | 25 | ||
| 9 | Cambuur | 27 | 10 | 3 | 14 | 43 | 58 | -15 | 33 | LLLW | 13 | 5 | 1 | 7 | 25 | 29 | 14 | 5 | 2 | 7 | 18 | 29 | ||
| 10 | NEC | 27 | 8 | 8 | 11 | 33 | 43 | -10 | 32 | OLLL | 13 | 2 | 5 | 6 | 12 | 18 | 14 | 6 | 3 | 5 | 21 | 25 | ||
| 11 | 1 | SC Heerenveen | 27 | 8 | 6 | 13 | 24 | 36 | -12 | 30 | WOOL | 14 | 4 | 2 | 8 | 14 | 21 | 13 | 4 | 4 | 5 | 10 | 15 | |
| 12 | 1 | Go Ahead Eagles | 27 | 8 | 6 | 13 | 30 | 43 | -13 | 30 | WLXW | 14 | 6 | 1 | 7 | 20 | 21 | 13 | 2 | 5 | 6 | 10 | 22 | |
| 13 | 2 | Heracles Almelo | 27 | 7 | 6 | 14 | 27 | 37 | -10 | 27 | LOLW | 14 | 7 | 4 | 3 | 19 | 13 | 13 | 0 | 2 | 11 | 8 | 24 | |
| 14 | RKC Waalwijk | 27 | 6 | 9 | 12 | 30 | 43 | -13 | 27 | WOLL | 13 | 4 | 2 | 7 | 11 | 21 | 14 | 2 | 7 | 5 | 19 | 22 | ||
| 15 | Willem II | 27 | 6 | 5 | 16 | 23 | 46 | -23 | 23 | XLOL | 14 | 4 | 3 | 7 | 12 | 20 | 13 | 2 | 2 | 9 | 11 | 26 | ||
| 16 | Fortuna Sittard | 26 | 6 | 4 | 16 | 26 | 58 | -32 | 22 | LWLL | 12 | 4 | 2 | 6 | 14 | 24 | 14 | 2 | 2 | 10 | 12 | 34 | ||
| 17 | Sparta | 25 | 4 | 9 | 12 | 19 | 37 | -18 | 21 | OWLW | 14 | 3 | 5 | 6 | 12 | 19 | 11 | 1 | 4 | 6 | 7 | 18 | ||
| 18 | PEC Zwolle | 27 | 5 | 5 | 17 | 20 | 42 | -22 | 20 | LLWL | 13 | 2 | 4 | 7 | 9 | 15 | 14 | 3 | 1 | 10 | 11 | 27 | ||
| 20 | +1 | Sébastien HALLER (Ajax, 1p) |
| 14 | +1 | Guus TIL (Feyenoord) |
| 13 | Jesper KARLSSON (AZ, 4p) | |
| 12 | +1 | Loïs OPENDA (Vitesse, 2p) |
| Ricky VAN WOLFSWINKEL (FC Twente, 5p) | ||
| 11 | +1 | Jørgen LARSEN (FC Groningen) |
| Bryan LINSSEN (Feyenoord) | ||
| 10 | +1 | Dušan TADIĆ (Ajax, 2p) |
| Vangelis PAVLIDIS (AZ) | ||
| +1 | Luis SINISTERRA (Feyenoord) | |
| 9 | Michiel KRAMER (RKC Waalwijk) | |
| 8 | +1 | Bart RAMSELAAR (FC Utrecht, 1p) |
| Henk VEERMAN (FC Utrecht, 2p) | ||
| +1 | Luuk BROUWERS (Go Ahead Eagles, 1p) | |
| Cody GAKPO (PSV, 1p) | ||
| +1 | ANTONY Matheus (Ajax) | |
| Jens ODGAARD (RKC Waalwijk) | ||
| IÑIGO CÓRDOBA Querejeta (Go Ahead Eagles) | ||
| +1 | Eran ZEHAVI (PSV) | |
| Mats SEUNTJENS (Fortuna Sittard, 2p) | ||
| 7 | Dani DE WIT (AZ) | |
| Nikolai BADEN FREDERIKSEN (Vitesse) | ||
| Anastasios DOUVIKAS (FC Utrecht, 2p) | ||
| Cyril NGONGE (FC Groningen) |
| Friday, 18 March 2022 | |||||
| SC Heerenveen | 2-0 | Heracles Almelo | |||
| 59 | Sarr | ||||
| 88 | Bakker | ||||
| Saturday, 19 March 2022 | |||||
| FC Twente | 1-0 | PEC Zwolle | |||
| 19 | Rots | ||||
| NEC | 0-0 | Sparta | |||
| Go Ahead Eagles | 3-0 | Cambuur | |||
| 25 | Kramer | ||||
| 36 | Brouwers | ||||
| 77 | Deijl | ||||
| Sunday, 20 March 2022 | |||||
| Willem II | 2-2 | AZ | |||
| 7 | Nunnely | 35 | Martins-Indi | ||
| 17 | Kabangu | 90 | Aboukhlal | ||
| FC Utrecht | 1-3 | FC Groningen | |||
| 48 | Ramselaar | 4(p) | El Hankouri | ||
| 10 | De Leeuw | ||||
| 89 | Larsen | ||||
| Vitesse | 1-2 | RKC Waalwijk | |||
| 6 | Openda | 15 | Meulensteen | ||
| 51 | Buttner | ||||
| Ajax | 3-2 | Feyenoord | |||
| 24 | Haller | 8 | Sinisterra | ||
| 78 | Tadić | 28 | Til | ||
| 86 | Antony | ||||
| PSV | 5-0 | Fortuna Sittard | |||
| 10 | Max | ||||
| 39 | Doan | ||||
| 41 | Zehavi | ||||
| 77 | Bruma | ||||
| 82 | Vinicius | ||||