| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 259 | 741 | 2.86 | 113 | 43.63% | 54 | 20.85% | 92 | 35.52% |
| 2021/22 | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Ajax | 29 | 23 | 3 | 3 | 85 | 15 | +70 | 72 | WWWW | 15 | 12 | 1 | 2 | 54 | 8 | 14 | 11 | 2 | 1 | 31 | 7 | ||
| 2 | PSV | 29 | 22 | 2 | 5 | 73 | 34 | +39 | 68 | WXWW | 15 | 12 | 0 | 3 | 42 | 18 | 14 | 10 | 2 | 2 | 31 | 16 | ||
| 3 | Feyenoord | 29 | 19 | 4 | 6 | 67 | 28 | +39 | 61 | WWLW | 14 | 10 | 2 | 2 | 34 | 12 | 15 | 9 | 2 | 4 | 33 | 16 | ||
| 4 | 1 | FC Twente | 29 | 17 | 7 | 5 | 46 | 33 | +13 | 58 | WXWW | 14 | 8 | 5 | 1 | 22 | 11 | 15 | 9 | 2 | 4 | 24 | 22 | |
| 5 | 1 | AZ | 29 | 17 | 4 | 8 | 56 | 35 | +21 | 55 | LWXL | 14 | 10 | 2 | 2 | 31 | 14 | 15 | 7 | 2 | 6 | 25 | 21 | |
| 6 | 1 | Vitesse | 28 | 13 | 5 | 10 | 35 | 43 | -8 | 44 | WLLO | 14 | 6 | 2 | 6 | 17 | 24 | 14 | 7 | 3 | 4 | 18 | 19 | |
| 7 | 1 | FC Utrecht | 29 | 11 | 9 | 9 | 46 | 38 | +8 | 42 | XXLL | 15 | 7 | 5 | 3 | 29 | 18 | 14 | 4 | 4 | 6 | 17 | 20 | |
| 8 | FC Groningen | 29 | 9 | 9 | 11 | 37 | 43 | -6 | 36 | LLWW | 14 | 4 | 6 | 4 | 15 | 15 | 15 | 5 | 3 | 7 | 22 | 28 | ||
| 9 | 1 | Go Ahead Eagles | 29 | 10 | 6 | 13 | 35 | 43 | -8 | 36 | WWWL | 15 | 7 | 1 | 7 | 24 | 21 | 14 | 3 | 5 | 6 | 11 | 22 | |
| 10 | 1 | NEC | 29 | 9 | 8 | 12 | 35 | 46 | -11 | 35 | LWOL | 14 | 2 | 5 | 7 | 12 | 20 | 15 | 7 | 3 | 5 | 23 | 26 | |
| 11 | 1 | SC Heerenveen | 29 | 9 | 7 | 13 | 28 | 38 | -10 | 34 | WXWO | 15 | 5 | 2 | 8 | 17 | 22 | 14 | 4 | 5 | 5 | 11 | 16 | |
| 12 | 1 | Cambuur | 29 | 10 | 3 | 16 | 44 | 61 | -17 | 33 | LLLL | 14 | 5 | 1 | 8 | 26 | 31 | 15 | 5 | 2 | 8 | 18 | 30 | |
| 13 | Heracles Almelo | 29 | 8 | 6 | 15 | 30 | 41 | -11 | 30 | LWLO | 15 | 7 | 4 | 4 | 20 | 17 | 14 | 1 | 2 | 11 | 10 | 24 | ||
| 14 | RKC Waalwijk | 29 | 6 | 10 | 13 | 31 | 46 | -15 | 28 | LXWO | 14 | 4 | 3 | 7 | 12 | 22 | 15 | 2 | 7 | 6 | 19 | 24 | ||
| 15 | 3 | PEC Zwolle | 29 | 6 | 5 | 18 | 22 | 44 | -22 | 23 | WLLL | 15 | 3 | 4 | 8 | 11 | 17 | 14 | 3 | 1 | 10 | 11 | 27 | |
| 16 | 1 | Willem II | 29 | 6 | 5 | 18 | 23 | 52 | -29 | 23 | LLXL | 14 | 4 | 3 | 7 | 12 | 20 | 15 | 2 | 2 | 11 | 11 | 32 | |
| 17 | Fortuna Sittard | 28 | 6 | 5 | 17 | 27 | 61 | -34 | 23 | XLLW | 13 | 4 | 2 | 7 | 14 | 26 | 15 | 2 | 3 | 10 | 13 | 35 | ||
| 18 | 2 | Sparta | 27 | 4 | 10 | 13 | 21 | 40 | -19 | 22 | LXOW | 15 | 3 | 6 | 6 | 13 | 20 | 12 | 1 | 4 | 7 | 8 | 20 | |
| 20 | Sébastien HALLER (Ajax, 1p) | |
| 15 | +1 | Guus TIL (Feyenoord) |
| 14 | Ricky VAN WOLFSWINKEL (FC Twente, 5p) | |
| Jesper KARLSSON (AZ, 5p) | ||
| 13 | +1 | Loïs OPENDA (Vitesse, 2p) |
| 12 | +1 | Dušan TADIĆ (Ajax, 4p) |
| +1 | Vangelis PAVLIDIS (AZ) | |
| Jørgen LARSEN (FC Groningen) | ||
| Bryan LINSSEN (Feyenoord) | ||
| 11 | Luis SINISTERRA (Feyenoord) | |
| 10 | Michiel KRAMER (RKC Waalwijk) | |
| 9 | +1 | Bart RAMSELAAR (FC Utrecht, 1p) |
| Cody GAKPO (PSV, 1p) | ||
| +1 | IÑIGO CÓRDOBA Querejeta (Go Ahead Eagles) | |
| 8 | Henk VEERMAN (FC Utrecht, 2p) | |
| Luuk BROUWERS (Go Ahead Eagles, 1p) | ||
| ANTONY Matheus (Ajax) | ||
| Jens ODGAARD (RKC Waalwijk) | ||
| Eran ZEHAVI (PSV) | ||
| Mats SEUNTJENS (Fortuna Sittard, 2p) | ||
| 7 | Dani DE WIT (AZ) | |
| Nikolai BADEN FREDERIKSEN (Vitesse) | ||
| +1 | Orkun KÖKÇÜ (Feyenoord, 2p) | |
| +1 | Zian FLEMMING (Fortuna Sittard) | |
| Anastasios DOUVIKAS (FC Utrecht, 2p) | ||
| Steven BERGHUIS (Ajax) | ||
| Cyril NGONGE (FC Groningen) | ||
| +1 | Davy KLAASSEN (Ajax) | |
| +1 | Joey VEERMAN (PSV) |
| Friday, 8 April 2022 | |||||
| Go Ahead Eagles | 4-0 | Willem II | |||
| 26 | Lidberg | ||||
| 34 | Iñigo Córdoba | ||||
| 70 | Heil | ||||
| 81 | Marc | ||||
| Saturday, 9 April 2022 | |||||
| FC Utrecht | 1-1 | Fortuna Sittard | |||
| 5 | Ramselaar | 61 | Flemming | ||
| NEC | 0-2 | FC Twente | |||
| 65 | Misidjan | ||||
| 75 | Limnios | ||||
| Ajax | 2-1 | Sparta | |||
| 49 | Klaassen | 33 | De Kamps | ||
| 62(p) | Tadić | ||||
| Sunday, 10 April 2022 | |||||
| SC Heerenveen | 3-1 | FC Groningen | |||
| 7 | van Hooijdonk | 29 | Kasanwirjo | ||
| 53 | van Hooijdonk | ||||
| 80 | van Beek | ||||
| Heracles Almelo | 1-4 | Feyenoord | |||
| 1 | Sinan | 21 | Kökçü | ||
| 39 | Nelson | ||||
| 45 | Til | ||||
| 70 | Wålemark | ||||
| PEC Zwolle | 2-1 | AZ | |||
| 51 | Kastaneer | 81 | Pavlidis | ||
| 86 | Redan | ||||
| Vitesse | 1-0 | Cambuur | |||
| 42 | Openda | ||||
| PSV | 2-0 | RKC Waalwijk | |||
| 38 | Veerman | ||||
| 69 | Teze | ||||