| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 193 | 562 | 2.91 | 83 | 43.01% | 39 | 20.21% | 71 | 36.79% |
| 2021/22 | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Ajax | 21 | 16 | 3 | 2 | 64 | 5 | +59 | 51 | WWWW | 11 | 8 | 1 | 2 | 41 | 3 | 10 | 8 | 2 | 0 | 23 | 2 | ||
| 2 | PSV | 22 | 16 | 1 | 5 | 54 | 28 | +26 | 49 | WLLW | 11 | 8 | 0 | 3 | 29 | 16 | 11 | 8 | 1 | 2 | 25 | 12 | ||
| 3 | Feyenoord | 21 | 14 | 3 | 4 | 50 | 19 | +31 | 45 | WWLW | 11 | 8 | 1 | 2 | 28 | 10 | 10 | 6 | 2 | 2 | 22 | 9 | ||
| 4 | FC Twente | 21 | 12 | 5 | 4 | 34 | 22 | +12 | 41 | WWWX | 10 | 6 | 3 | 1 | 15 | 6 | 11 | 6 | 2 | 3 | 19 | 16 | ||
| 5 | AZ | 21 | 12 | 3 | 6 | 39 | 25 | +14 | 39 | WOWW | 10 | 7 | 2 | 1 | 24 | 10 | 11 | 5 | 1 | 5 | 15 | 15 | ||
| 6 | Vitesse | 22 | 11 | 3 | 8 | 27 | 36 | -9 | 36 | LLLW | 11 | 4 | 2 | 5 | 11 | 21 | 11 | 7 | 1 | 3 | 16 | 15 | ||
| 7 | FC Utrecht | 22 | 10 | 5 | 7 | 39 | 29 | +10 | 35 | LWWL | 11 | 7 | 3 | 1 | 26 | 12 | 11 | 3 | 2 | 6 | 13 | 17 | ||
| 8 | Cambuur | 22 | 9 | 3 | 10 | 38 | 47 | -9 | 30 | LLOX | 11 | 4 | 1 | 6 | 21 | 25 | 11 | 5 | 2 | 4 | 17 | 22 | ||
| 9 | NEC | 21 | 7 | 6 | 8 | 26 | 31 | -5 | 27 | XLOW | 10 | 2 | 3 | 5 | 10 | 14 | 11 | 5 | 3 | 3 | 16 | 17 | ||
| 10 | 1 | FC Groningen | 22 | 6 | 7 | 9 | 25 | 31 | -6 | 25 | LWWL | 11 | 2 | 6 | 3 | 9 | 9 | 11 | 4 | 1 | 6 | 16 | 22 | |
| 11 | 1 | SC Heerenveen | 21 | 7 | 4 | 10 | 20 | 30 | -10 | 25 | LLLL | 11 | 3 | 2 | 6 | 11 | 18 | 10 | 4 | 2 | 4 | 9 | 12 | |
| 12 | 2 | Heracles Almelo | 22 | 6 | 5 | 11 | 23 | 30 | -7 | 23 | WLXO | 12 | 6 | 3 | 3 | 17 | 13 | 10 | 0 | 2 | 8 | 6 | 17 | |
| 13 | 1 | RKC Waalwijk | 21 | 5 | 7 | 9 | 24 | 34 | -10 | 22 | LWWX | 10 | 4 | 1 | 5 | 10 | 17 | 11 | 1 | 6 | 4 | 14 | 17 | |
| 14 | 1 | Go Ahead Eagles | 21 | 6 | 4 | 11 | 21 | 34 | -13 | 22 | LXLL | 10 | 4 | 0 | 6 | 13 | 15 | 11 | 2 | 4 | 5 | 8 | 19 | |
| 15 | Willem II | 21 | 6 | 3 | 12 | 21 | 40 | -19 | 21 | WLLL | 11 | 4 | 1 | 6 | 10 | 17 | 10 | 2 | 2 | 6 | 11 | 23 | ||
| 16 | Fortuna Sittard | 22 | 5 | 4 | 13 | 24 | 50 | -26 | 19 | WWLL | 10 | 3 | 2 | 5 | 13 | 23 | 12 | 2 | 2 | 8 | 11 | 27 | ||
| 17 | 1 | PEC Zwolle | 22 | 4 | 4 | 14 | 17 | 36 | -19 | 16 | WXWW | 11 | 2 | 3 | 6 | 7 | 12 | 11 | 2 | 1 | 8 | 10 | 24 | |
| 18 | 1 | Sparta | 21 | 2 | 8 | 11 | 16 | 35 | -19 | 14 | LLXX | 11 | 1 | 5 | 5 | 9 | 17 | 10 | 1 | 3 | 6 | 7 | 18 | |
| 13 | +2 | Guus TIL (Feyenoord) |
| +1 | Sébastien HALLER (Ajax, 1p) | |
| 11 | Loïs OPENDA (Vitesse, 2p) | |
| Ricky VAN WOLFSWINKEL (FC Twente, 5p) | ||
| Bryan LINSSEN (Feyenoord) | ||
| 9 | +2 | Jørgen LARSEN (FC Groningen) |
| Jesper KARLSSON (AZ, 2p) | ||
| 8 | Henk VEERMAN (FC Utrecht, 2p) | |
| +1 | Michiel KRAMER (RKC Waalwijk) | |
| Mats SEUNTJENS (Fortuna Sittard, 2p) | ||
| 7 | Dani DE WIT (AZ) | |
| Nikolai BADEN FREDERIKSEN (Vitesse) | ||
| Anastasios DOUVIKAS (FC Utrecht, 2p) | ||
| Dušan TADIĆ (Ajax, 1p) | ||
| Vangelis PAVLIDIS (AZ) | ||
| +1 | Cody GAKPO (PSV, 1p) | |
| ANTONY Matheus (Ajax) | ||
| Cyril NGONGE (FC Groningen) | ||
| Jens ODGAARD (RKC Waalwijk) | ||
| Luis SINISTERRA (Feyenoord) | ||
| 6 | Bart RAMSELAAR (FC Utrecht, 1p) | |
| IÑIGO CÓRDOBA Querejeta (Go Ahead Eagles) | ||
| Yorbe VERTESSEN (PSV) |
| Sunday, 6 February 2022 | |||||
| Feyenoord | 4-0 | Sparta | |||
| 4 | Kökçü | ||||
| 11 | Jahanbakhsh | ||||
| 50 | Til | ||||
| 70 | Til | ||||
| Willem II | 3-1 | RKC Waalwijk | |||
| 8 | Oosting | 71 | Kramer | ||
| 13 | Oosting | ||||
| 43 | Hornkamp | ||||
| FC Groningen | 2-1 | Go Ahead Eagles | |||
| 4 | Larsen | 60 | Botos | ||
| 69 | Larsen | ||||
| Ajax | 3-0 | Heracles Almelo | |||
| 22 | Klaassen | ||||
| 55 | Haller | ||||
| 65 | Taylor | ||||
| Friday, 11 February 2022 | |||||
| Heracles Almelo | 1-0 | FC Utrecht | |||
| 82 | Sierhuis | ||||
| Saturday, 12 February 2022 | |||||
| FC Groningen | 0-1 | Fortuna Sittard | |||
| 82 | Siovas | ||||
| Cambuur | 3-4 | PEC Zwolle | |||
| 9(p) | Maulun | 3 | Darfalou | ||
| 43(og) | Lamprou | 6 | De Wit | ||
| 78 | Sambissa | 56 | Redan | ||
| 66 | van Polen | ||||
| Vitesse | 0-5 | PSV | |||
| 4 | Zehavi | ||||
| 24 | Mauro Júnior | ||||
| 28 | Gakpo | ||||
| 62 | Vinicius | ||||
| 88 | Doan | ||||