| ROUND | P | Q1 | Q2 | Q3 | ||||
| ol1 | ol2 | l1 | l2 | l1 | l2 | l1 | l2 | |
| Tuesday, 17 August 2021 | ||||||
| l1 |  KuPS | - | 1.FC Union Berlin | |||
| Thursday, 19 August 2021 | ||||||
| l1 |  Feyenoord | - | Elfsborg | |||
| l1 |  Rennes | - | Rosenborg | |||
| l1 |  Trabzonspor | - | Roma | |||
| l1 |  Anderlecht | - | Vitesse | |||
| l1 |  Paços Ferreira | - | Tottenham Hotspur | |||
| l1 |  Viktoria Plzeň | - | CSKA | |||
| l1 | Jablonec | - | MŠK Žilina | |||
| l1 |  FC Basel | - | Hammarby | |||
| l1 |  LASK | - | St.Johnstone | |||
| l1 |  PAOK | - | Rijeka | |||
| l1 |  Flora | - | Shamrock Rovers | |||
| l1 | Santa Clara | - | Partizan | |||
| l1 |  Žalgiris | - | Bodø/Glimt | |||
| l1 |  Neftçi | - | Maccabi Haifa | |||
| l1 |  Domagnano | - | Aberdeen | |||
| l1 | Hapoel Beer Sheva | - | Anorthosis | |||
| l1 |  Raków Częstochowa | - | AA Gent | |||
| l1 | Sivasspor | - | FC København | |||
| l1 |  Shakhter | - | Maccabi Tel Aviv | |||
| l1 |  Fola | - | Kairat | |||
| l1 |  Rīga | - | Lincoln Red Imps | |||
