| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 |
| 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 187 | 585 | 3.12 | 103 | 55.08% | 33 | 17.65% | 51 | 27.27% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Metrostars | 31 | 17 | 3 | 11 | 61 | 52 | +9 | 54 | WLWO | 16 | 9 | 3 | 4 | 32 | 24 | 15 | 8 | 0 | 7 | 29 | 28 | ||
| 2 | New England Revolution | 31 | 12 | 6 | 13 | 43 | 46 | -3 | 42 | LLWW | 15 | 8 | 3 | 4 | 23 | 17 | 16 | 4 | 3 | 9 | 20 | 29 | ||
| 3 | Miami Fusion | 31 | 11 | 5 | 15 | 48 | 54 | -6 | 38 | LWLL | 16 | 8 | 3 | 5 | 31 | 26 | 15 | 3 | 2 | 10 | 17 | 28 | ||
| 4 | D.C. United | 31 | 8 | 6 | 17 | 42 | 57 | -15 | 30 | WLWL | 15 | 6 | 3 | 6 | 23 | 25 | 16 | 2 | 3 | 11 | 19 | 32 | ||
| Central | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Chicago Fire | 31 | 16 | 6 | 9 | 64 | 49 | +15 | 54 | WWWX | 16 | 13 | 1 | 2 | 40 | 18 | 15 | 3 | 5 | 7 | 24 | 31 | ||
| 2 | Tampa Bay Mutiny | 31 | 16 | 3 | 12 | 60 | 48 | +12 | 51 | LWXL | 15 | 10 | 1 | 4 | 36 | 21 | 16 | 6 | 2 | 8 | 24 | 27 | ||
| 3 | Dallas Burn | 31 | 13 | 4 | 14 | 52 | 53 | -1 | 43 | WLLW | 15 | 10 | 2 | 3 | 35 | 21 | 16 | 3 | 2 | 11 | 17 | 32 | ||
| 4 | Columbus Crew | 31 | 11 | 5 | 15 | 46 | 55 | -9 | 38 | LLLL | 15 | 7 | 3 | 5 | 27 | 22 | 16 | 4 | 2 | 10 | 19 | 33 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Kansas City Wizards | 31 | 16 | 8 | 7 | 45 | 27 | +18 | 56 | WWXO | 16 | 11 | 1 | 4 | 27 | 14 | 15 | 5 | 7 | 3 | 18 | 13 | ||
| 2 | LA Galaxy | 32 | 14 | 8 | 10 | 47 | 37 | +10 | 50 | LLWW | 16 | 8 | 5 | 3 | 20 | 15 | 16 | 6 | 3 | 7 | 27 | 22 | ||
| 3 | Colorado Rapids | 32 | 13 | 4 | 15 | 43 | 59 | -16 | 43 | WLWX | 16 | 8 | 3 | 5 | 19 | 21 | 16 | 5 | 1 | 10 | 24 | 38 | ||
| 4 | San Jose Clash | 31 | 7 | 8 | 16 | 34 | 48 | -14 | 29 | WLLW | 16 | 5 | 5 | 6 | 26 | 22 | 15 | 2 | 3 | 10 | 8 | 26 | ||
| 26 | Mamadou DIALLO (Tampa Bay Mutiny, 1p) | |
| 17 | +1 | Ante RAZOV (Chicago Fire, 2p) |
| 16 | Adolfo VALENCIA (Metrostars, 4p) | |
| Clint MATHIS (Metrostars, 1p) | ||
| 15 | Wolde HARRIS (New England Revolution) | |
| Dante WASHINGTON (Columbus Crew) | ||
| 14 | Ariel GRAZIANI (Dallas Burn) | |
| 13 | Diego SERNA (Miami Fusion, 1p) | |
| 12 | Jaime MORENO (D.C. United, 1p) | |
| 11 | Jason KREIS (Dallas Burn) | |
| +1 | Miklos MOLNAR (Kansas City Wizards) | |
| 10 | Junior AGOGO (Colorado Rapids, 1p) | |
| Alex COMAS (Metrostars, 2p) | ||
| Dmytro KOVALENKO (Chicago Fire) | ||
| 9 | +1 | Hristo STOICHKOV (Chicago Fire, 3p) |
| Raul ARCE (D.C. United) | ||
| 8 | Manny LAGOS (Tampa Bay Mutiny) | |
| Chris HENDERSON (Kansas City Wizards) | ||
| Roy LASSITER (Miami Fusion, 1p) | ||
| Abdul CONTEH (San Jose Clash) | ||
| Imad BABA (New England Revolution, 2p) |
| Wednesday, 6 September 2000 | |||||
| New England Revolution | 0-1 | Kansas City Wizards | |||
| 50 | Molnar | ||||
| LA Galaxy | 0-1 | Dallas Burn | |||
| 37 | Rodriguez | ||||
| Chicago Fire | 3-1 | Columbus Crew | |||
| 8 | Soehn | 59 | Elcock | ||
| 40 | Razov | ||||
| 81(p) | Stoichkov | ||||
| Friday, 8 September 2000 | |||||
| Colorado Rapids | 1-0 | LA Galaxy | |||
| 90 | Bravo | ||||