| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 |
| 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 118 | 368 | 3.11 | 65 | 55.08% | 24 | 20.34% | 29 | 24.58% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Metrostars | 18 | 9 | 2 | 7 | 30 | 26 | +4 | 29 | WOWX | 10 | 4 | 2 | 4 | 17 | 16 | 8 | 5 | 0 | 3 | 13 | 10 | |
| 2 | 1 | New England Revolution | 19 | 7 | 5 | 7 | 31 | 29 | +2 | 26 | LLXL | 8 | 5 | 2 | 1 | 16 | 9 | 11 | 2 | 3 | 6 | 15 | 20 | |
| 3 | Miami Fusion | 19 | 7 | 4 | 8 | 26 | 28 | -2 | 25 | WLWL | 11 | 5 | 3 | 3 | 17 | 15 | 8 | 2 | 1 | 5 | 9 | 13 | ||
| 4 | D.C. United | 21 | 4 | 5 | 12 | 30 | 42 | -12 | 17 | LXLW | 10 | 3 | 2 | 5 | 14 | 19 | 11 | 1 | 3 | 7 | 16 | 23 | ||
| Central | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Tampa Bay Mutiny | 20 | 11 | 0 | 9 | 40 | 31 | +9 | 33 | WLWW | 10 | 7 | 0 | 3 | 25 | 13 | 10 | 4 | 0 | 6 | 15 | 18 | ||
| 2 | Chicago Fire | 20 | 9 | 3 | 8 | 42 | 37 | +5 | 30 | LXXW | 9 | 7 | 0 | 2 | 23 | 13 | 11 | 2 | 3 | 6 | 19 | 24 | ||
| 3 | Columbus Crew | 20 | 7 | 4 | 9 | 28 | 34 | -6 | 25 | LWLW | 11 | 4 | 3 | 4 | 16 | 17 | 9 | 3 | 1 | 5 | 12 | 17 | ||
| 4 | Dallas Burn | 20 | 7 | 3 | 10 | 32 | 37 | -5 | 24 | WLLO | 10 | 7 | 1 | 2 | 23 | 14 | 10 | 0 | 2 | 8 | 9 | 23 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Kansas City Wizards | 18 | 11 | 5 | 2 | 30 | 12 | +18 | 38 | OWOL | 9 | 8 | 1 | 0 | 18 | 3 | 9 | 3 | 4 | 2 | 12 | 9 | ||
| 2 | LA Galaxy | 21 | 9 | 7 | 5 | 28 | 23 | +5 | 34 | WLWL | 11 | 6 | 4 | 1 | 15 | 10 | 10 | 3 | 3 | 4 | 13 | 13 | ||
| 3 | Colorado Rapids | 20 | 9 | 2 | 9 | 27 | 39 | -12 | 29 | WXWL | 10 | 5 | 1 | 4 | 11 | 17 | 10 | 4 | 1 | 5 | 16 | 22 | ||
| 4 | San Jose Clash | 20 | 4 | 8 | 8 | 24 | 30 | -6 | 20 | OLOX | 9 | 4 | 5 | 0 | 19 | 8 | 11 | 0 | 3 | 8 | 5 | 22 | ||
| 17 | +1 | Mamadou DIALLO (Tampa Bay Mutiny) |
| 11 | Ante RAZOV (Chicago Fire, 1p) | |
| 10 | +2 | Ariel GRAZIANI (Dallas Burn) |
| +1 | Jason KREIS (Dallas Burn) | |
| +1 | Dante WASHINGTON (Columbus Crew) | |
| 9 | Adolfo VALENCIA (Metrostars, 1p) | |
| Jaime MORENO (D.C. United, 1p) | ||
| 8 | +1 | Wolde HARRIS (New England Revolution) |
| Miklos MOLNAR (Kansas City Wizards) | ||
| 7 | Junior AGOGO (Colorado Rapids, 1p) | |
| Abdul CONTEH (San Jose Clash) | ||
| Diego SERNA (Miami Fusion) | ||
| Clint MATHIS (Metrostars) | ||
| 6 | +1 | Raul ARCE (D.C. United) |
| Dmytro KOVALENKO (Chicago Fire) | ||
| Imad BABA (New England Revolution, 1p) | ||
| 5 | Manny LAGOS (Tampa Bay Mutiny) | |
| Chris HENDERSON (Kansas City Wizards) | ||
| Hristo STOICHKOV (Chicago Fire) | ||
| Cobi JONES (LA Galaxy) | ||
| +1 | Greg VANNEY (LA Galaxy, 5p) | |
| Ted CHRONOPOULOS (New England Revolution) | ||
| Josh WOLFF (Chicago Fire) |
| Saturday, 1 July 2000 | |||||
| D.C. United | 1-1 | Colorado Rapids | |||
| 49 | Arce | 90 | Okoh | ||
| Dallas Burn | 4-2 | LA Galaxy | |||
| 26 | Graziani | 82 | Hernández | ||
| 38 | Graziani | 90(p) | Vanney | ||
| 47 | Eck | ||||
| 80 | Kreis | ||||
| Columbus Crew | 2-1 | San Jose Clash | |||
| 83(p) | Warzycha | 48 | Krakowiak | ||
| 84 | Washington | ||||
| Tampa Bay Mutiny | 0-2 | Metrostars | |||
| 38 | Chung | ||||
| 86 | Villegas | ||||
| Tuesday, 4 July 2000 | |||||
| San Jose Clash | 0-0 | Kansas City Wizards | |||
| Colorado Rapids | 2-1 | Chicago Fire | |||
| 89 | Limpar | 45 | Lewis | ||
| 90 | Balboa | ||||
| Tampa Bay Mutiny | 3-0 | D.C. United | |||
| 26 | Diallo | ||||
| 37 | Quill | ||||
| 46 | Quill | ||||
| LA Galaxy | 1-0 | Columbus Crew | |||
| 4 | Cienfuegos | ||||
| Miami Fusion | 2-1 | New England Revolution | |||
| 30(p) | Gutierrez | 3 | Harris | ||
| 55 | Rooney | ||||