| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 |
| 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 139 | 430 | 3.09 | 73 | 52.52% | 28 | 20.14% | 38 | 27.34% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Metrostars | 22 | 13 | 2 | 7 | 39 | 29 | +10 | 41 | WWWW | 12 | 6 | 2 | 4 | 23 | 19 | 10 | 7 | 0 | 3 | 16 | 10 | ||
| 2 | New England Revolution | 23 | 9 | 5 | 9 | 35 | 36 | -1 | 32 | WWLL | 9 | 5 | 2 | 2 | 16 | 11 | 14 | 4 | 3 | 7 | 19 | 25 | ||
| 3 | Miami Fusion | 23 | 7 | 5 | 11 | 32 | 41 | -9 | 26 | LXLL | 13 | 5 | 3 | 5 | 20 | 23 | 10 | 2 | 2 | 6 | 12 | 18 | ||
| 4 | D.C. United | 24 | 5 | 6 | 13 | 34 | 48 | -14 | 21 | WXLL | 11 | 3 | 3 | 5 | 16 | 21 | 13 | 2 | 3 | 8 | 18 | 27 | ||
| Central | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Tampa Bay Mutiny | 23 | 12 | 2 | 9 | 44 | 33 | +11 | 38 | WOXW | 11 | 8 | 0 | 3 | 27 | 13 | 12 | 4 | 2 | 6 | 17 | 20 | ||
| 2 | Chicago Fire | 23 | 10 | 5 | 8 | 46 | 39 | +7 | 35 | XOWL | 11 | 8 | 1 | 2 | 26 | 14 | 12 | 2 | 4 | 6 | 20 | 25 | ||
| 3 | 1 | Dallas Burn | 24 | 9 | 4 | 11 | 40 | 40 | +0 | 31 | XWWL | 12 | 8 | 2 | 2 | 27 | 15 | 12 | 1 | 2 | 9 | 13 | 25 | |
| 4 | 1 | Columbus Crew | 24 | 9 | 4 | 11 | 36 | 41 | -5 | 31 | LWWL | 13 | 6 | 3 | 4 | 22 | 18 | 11 | 3 | 1 | 7 | 14 | 23 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Kansas City Wizards | 22 | 12 | 5 | 5 | 33 | 17 | +16 | 41 | WLLL | 12 | 9 | 1 | 2 | 21 | 6 | 10 | 3 | 4 | 3 | 12 | 11 | ||
| 2 | LA Galaxy | 24 | 10 | 7 | 7 | 34 | 30 | +4 | 37 | LLWW | 12 | 6 | 4 | 2 | 16 | 12 | 12 | 4 | 3 | 5 | 18 | 18 | ||
| 3 | Colorado Rapids | 23 | 10 | 3 | 10 | 30 | 42 | -12 | 33 | XWLW | 12 | 5 | 2 | 5 | 12 | 19 | 11 | 5 | 1 | 5 | 18 | 23 | ||
| 4 | San Jose Clash | 23 | 5 | 8 | 10 | 27 | 34 | -7 | 23 | LLWO | 11 | 4 | 5 | 2 | 21 | 12 | 12 | 1 | 3 | 8 | 6 | 22 | ||
| 18 | +1 | Mamadou DIALLO (Tampa Bay Mutiny) |
| 14 | Dante WASHINGTON (Columbus Crew) | |
| 13 | Ariel GRAZIANI (Dallas Burn) | |
| 12 | Ante RAZOV (Chicago Fire, 1p) | |
| 10 | +1 | Adolfo VALENCIA (Metrostars, 2p) |
| +1 | Junior AGOGO (Colorado Rapids, 1p) | |
| +2 | Wolde HARRIS (New England Revolution) | |
| Jason KREIS (Dallas Burn) | ||
| Jaime MORENO (D.C. United, 1p) | ||
| 9 | Clint MATHIS (Metrostars) | |
| 8 | Abdul CONTEH (San Jose Clash) | |
| Miklos MOLNAR (Kansas City Wizards) | ||
| Dmytro KOVALENKO (Chicago Fire) | ||
| 7 | +2 | Chris HENDERSON (Kansas City Wizards) |
| Cobi JONES (LA Galaxy) | ||
| Raul ARCE (D.C. United) | ||
| Diego SERNA (Miami Fusion) | ||
| 6 | Brian WEST (Columbus Crew) | |
| +2 | Alex COMAS (Metrostars) | |
| Imad BABA (New England Revolution, 1p) | ||
| 5 | Manny LAGOS (Tampa Bay Mutiny) | |
| +1 | Petter VILLEGAS (Metrostars) | |
| Hristo STOICHKOV (Chicago Fire) | ||
| +1 | Robert WARZYCHA (Columbus Crew, 1p) | |
| Greg VANNEY (LA Galaxy, 5p) | ||
| Ted CHRONOPOULOS (New England Revolution) | ||
| Josh WOLFF (Chicago Fire) | ||
| +1 | Jay HEAPS (Miami Fusion) |
| Wednesday, 19 July 2000 | |||||
| Dallas Burn | 1-1 | Miami Fusion | |||
| 21 | Rodriguez | 39 | McKinley | ||
| Kansas City Wizards | 0-1 | New England Revolution | |||
| 85 | Harris | ||||
| Friday, 21 July 2000 | |||||
| Colorado Rapids | 1-1 | Chicago Fire | |||
| 27 | Agogo | 35 | Bocanegra | ||
| Saturday, 22 July 2000 | |||||
| San Jose Clash | 1-2 | New England Revolution | |||
| 46 | Krakowiak | 16 | Sunsing | ||
| 63 | Harris | ||||
| Metrostars | 4-2 | Miami Fusion | |||
| 39 | Comas | 60 | Heaps | ||
| 49(p) | Valencia | 90 | Lassiter | ||
| 53 | Villegas | ||||
| 59 | Comas | ||||
| Tampa Bay Mutiny | 2-0 | LA Galaxy | |||
| 81 | Trittschuh | ||||
| 87 | Diallo | ||||
| Kansas City Wizards | 3-1 | Columbus Crew | |||
| 22 | Preki | 40 | Warzycha | ||
| 74 | Henderson | ||||
| 81 | Henderson | ||||