| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 230 | 602 | 2.61 | 122 | 53.04% | 46 | 20.00% | 62 | 26.96% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Sporting Kansas City | 25 | 14 | 4 | 7 | 31 | 22 | +9 | 46 | WWWL | 12 | 7 | 2 | 3 | 14 | 8 | 13 | 7 | 2 | 4 | 17 | 14 | ||
| 2 | New York Red Bulls | 24 | 12 | 5 | 7 | 40 | 34 | +6 | 41 | WLLW | 11 | 8 | 3 | 0 | 24 | 10 | 13 | 4 | 2 | 7 | 16 | 24 | ||
| 3 | 1 | Chicago Fire | 24 | 12 | 5 | 7 | 30 | 26 | +4 | 41 | WWWX | 12 | 8 | 2 | 2 | 17 | 11 | 12 | 4 | 3 | 5 | 13 | 15 | |
| 4 | 1 | Houston Dynamo | 24 | 11 | 7 | 6 | 35 | 27 | +8 | 40 | LWWW | 11 | 8 | 3 | 0 | 21 | 7 | 13 | 3 | 4 | 6 | 14 | 20 | |
| 5 | D.C. United | 22 | 11 | 3 | 8 | 36 | 29 | +7 | 36 | LWLL | 11 | 8 | 2 | 1 | 24 | 9 | 11 | 3 | 1 | 7 | 12 | 20 | ||
| 6 | Montréal Impact | 27 | 11 | 3 | 13 | 39 | 44 | -5 | 36 | WWWW | 14 | 9 | 2 | 3 | 28 | 18 | 13 | 2 | 1 | 10 | 11 | 26 | ||
| 7 | Columbus Crew | 21 | 8 | 5 | 8 | 21 | 22 | -1 | 29 | XLWW | 10 | 5 | 2 | 3 | 13 | 12 | 11 | 3 | 3 | 5 | 8 | 10 | ||
| 8 | New England Revolution | 24 | 6 | 5 | 13 | 27 | 31 | -4 | 23 | LLLL | 12 | 5 | 3 | 4 | 16 | 11 | 12 | 1 | 2 | 9 | 11 | 20 | ||
| 9 | Philadelphia Union | 21 | 7 | 2 | 12 | 23 | 27 | -4 | 23 | LLWL | 11 | 5 | 1 | 5 | 17 | 13 | 10 | 2 | 1 | 7 | 6 | 14 | ||
| 10 | Toronto FC | 24 | 5 | 5 | 14 | 27 | 43 | -16 | 20 | LXLL | 13 | 3 | 3 | 7 | 13 | 21 | 11 | 2 | 2 | 7 | 14 | 22 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | San Jose Earthquakes | 25 | 14 | 5 | 6 | 48 | 32 | +16 | 47 | LWXL | 12 | 8 | 3 | 1 | 28 | 14 | 13 | 6 | 2 | 5 | 20 | 18 | ||
| 2 | Real Salt Lake | 26 | 13 | 3 | 10 | 37 | 32 | +5 | 42 | LLLW | 14 | 9 | 1 | 4 | 24 | 14 | 12 | 4 | 2 | 6 | 13 | 18 | ||
| 3 | Seattle Sounders | 24 | 11 | 7 | 6 | 34 | 24 | +10 | 40 | WLWW | 12 | 8 | 1 | 3 | 18 | 7 | 12 | 3 | 6 | 3 | 16 | 17 | ||
| 4 | 1 | LA Galaxy | 26 | 11 | 4 | 11 | 44 | 40 | +4 | 37 | XWLW | 11 | 5 | 1 | 5 | 19 | 16 | 15 | 6 | 3 | 6 | 25 | 24 | |
| 5 | 1 | Vancouver Whitecaps | 26 | 10 | 7 | 9 | 28 | 33 | -5 | 37 | LLWL | 13 | 7 | 4 | 2 | 19 | 14 | 13 | 3 | 3 | 7 | 9 | 19 | |
| 6 | FC Dallas | 27 | 8 | 8 | 11 | 33 | 35 | -2 | 32 | WWWX | 14 | 5 | 6 | 3 | 17 | 13 | 13 | 3 | 2 | 8 | 16 | 22 | ||
| 7 | Chivas USA | 22 | 7 | 6 | 9 | 15 | 26 | -11 | 27 | XLWL | 12 | 3 | 2 | 7 | 6 | 15 | 10 | 4 | 4 | 2 | 9 | 11 | ||
| 8 | Colorado Rapids | 25 | 8 | 2 | 15 | 32 | 36 | -4 | 26 | XLWL | 13 | 6 | 2 | 5 | 22 | 14 | 12 | 2 | 0 | 10 | 10 | 22 | ||
| 9 | Portland Timbers | 23 | 5 | 6 | 12 | 22 | 39 | -17 | 21 | XXLL | 12 | 5 | 3 | 4 | 18 | 17 | 11 | 0 | 3 | 8 | 4 | 22 | ||
| 18 | +1 | Chris WONDOLOWSKI (San Jose Earthquakes) |
| 14 | +1 | Álvaro SABORIO (Real Salt Lake) |
| 13 | Kenny COOPER (New York Red Bulls) | |
| 11 | +1 | Eddie JOHNSON (Seattle Sounders) |
| +1 | Robbie KEANE (LA Galaxy) | |
| Thierry HENRY (New York Red Bulls) | ||
| 10 | Chris PONTIUS (D.C. United) | |
| Will BRUIN (Houston Dynamo) | ||
| 9 | Landon DONOVAN (LA Galaxy) | |
| +1 | Kei KAMARA (Sporting Kansas City) | |
| Danny KOEVERMANS (Toronto FC) | ||
| Alan GORDON (San Jose Earthquakes) | ||
| Saër SÈNE (New England Revolution) | ||
| 8 | Steven LENHART (San Jose Earthquakes) | |
| +1 | Fredy MONTERO (Seattle Sounders) | |
| 7 | Darren MATTOCKS (Vancouver Whitecaps) | |
| Kris BOYD (Portland Timbers) | ||
| +1 | Patrice BERNIER (Montréal Impact) | |
| MAICON CARIOCA (D.C. United) | ||
| 6 | Jaime CASTRILLÓN (Colorado Rapids) | |
| Edgar ESPÍNDOLA (Real Salt Lake) | ||
| Marco PAPPA (Chicago Fire) | ||
| David BECKHAM (LA Galaxy) |
| Wednesday, 15 August 2012 | |||||
| Toronto FC | 2-2 | Portland Timbers | |||
| 57 | Hassli | 21 | Zizzo | ||
| 63 | Silva | 82 | Nagbe | ||
| Vancouver Whitecaps | 0-2 | FC Dallas | |||
| 60 | Castillo | ||||
| 70 | Top | ||||
| Columbus Crew | 1-1 | LA Galaxy | |||
| 47 | Arrieta | 64 | Keane | ||
| Saturday, 18 August 2012 | |||||
| Chicago Fire | 2-1 | New England Revolution | |||
| 5 | Rolfe | 11 | Cardenas | ||
| 25 | Macdonald | ||||
| Montréal Impact | 3-1 | San Jose Earthquakes | |||
| 25 | Di Vaio | 23 | Wondolowski | ||
| 61 | Neagle | ||||
| 72 | Bernier | ||||
| Seattle Sounders | 2-0 | Vancouver Whitecaps | |||
| 64 | Montero | ||||
| 87 | Johnson | ||||
| Colorado Rapids | 1-1 | Chivas USA | |||
| 19 | Mullan | 83 | Ángel | ||
| Real Salt Lake | 1-2 | FC Dallas | |||
| 76 | Saborio | 61 | Castillo | ||
| 90 | Ferreira | ||||
| Toronto FC | 0-1 | Sporting Kansas City | |||
| 83 | Kamara | ||||