Results| Monday, 11 September 2000 |
| r1l1 |  Bohemians | 1-3 | Kaiserslautern |
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| Tuesday, 12 September 2000 |
| r1l1 |  AA Gent | 0-6 | Ajax |
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| r1l1 |  FC Basel | 3-2 | Brann |
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| r1l1 |  FK Drnovice | 0-0 | TSV München 1860 |
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| r1l1 | Lierse | 0-0 | Bordeaux |
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| r1l1 |  SK Rapid Wien | 3-0 | Örgryte |
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| r1l1 |  Vasas | 2-2 | AEK |
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| r1l1 | IFK Norrköping | 2-2 | Slovan Liberec |
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| r1l1 |  1.FC Košice* | 2-3 | GAK |
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| Thursday, 14 September 2000 |
| r1l1 |  Chelsea | 1-0 | St.Gallen |
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| r1l1 | Leicester City | 1-1 | Crvena Zvezda |
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| r1l1 | VfB Stuttgart | 1-0 | Hearts |
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| r1l1 |  Antalyaspor | 2-0 | SV Werder Bremen |
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| r1l1 |  Kryvbas* | 0-1 | Nantes |
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| r1l1 |  Celta Vigo | 0-0 | Rijeka |
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| r1l1 | Zaragoza | 4-1 | Wisła Kraków |
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| r1l1 | PAOK | 3-1 | Beitar Jerusalem |
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| r1l1 | Ruch Chorzów | 0-3 | Inter |
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| r1l1 | Slavia Praha | 3-0 | AB |
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| r1l1 |  Rapid București | 0-1 | Liverpool |
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| r1l1 | Dunaferr | 0-1 | Feyenoord |
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| r1l1 | Partizan | 1-1 | FC Porto |
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| r1l1 |  Pobeda | 0-2 | Parma |
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| r1l1 | Alavés | 0-0 | Gaziantepspor |
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| r1l1 | Wacker Innsbruck | 3-1 | Fiorentina |
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| r1l1 | Brøndby | 1-2 | Osijek |
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| r1l1 | Club Brugge | 2-0 | APOEL |
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| r1l1 |  CSKA | 0-0 | Viborg |
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| r1l1 | Halmstad | 2-1 | Benfica |
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| r1l1 | Celtic | 2-0 | HJK |
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| r1l1 | FC Zürich | 1-2 | Racing Genk |
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| r1l1 | Molde | 0-1 | Rayo Vallecano |
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| r1l1 | AIK | 0-1 | HB Køge |
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| r1l1 |  CSKA | 1-2 | MTK |
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| r1l1 | Lokomotiv | 4-2 | Naftex |
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| r1l1 | Vorskla-Naftohaz | 1-2 | Boavista |
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| r1l1 | Vitesse | 3-0 | Maccabi Haifa |
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| r1l1 | Polonia Warszawa | 0-1 | Udinese |
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| r1l1 | Lausanne | 3-2 | Torpedo |
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| r1l1 | Roda JC | 0-2 | Inter Bratislava |
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| r1l1 | Slovan Bratislava | 0-3 | Dinamo Zagreb |
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| r1l1 | Alania | 0-3 | Amica Wronki |
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| r1l1 | Gueugnon | 0-0 | Iraklis |
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| r1l1 |  Olimpija | 2-1 | Espanyol |
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| r1l1 | Lillestrøm | 3-1 | Dinamo |
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| r1l1 |  Zimbru | 1-2 | Hertha BSC Berlin |
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| r1l1 | Napredak Kruševac | 0-0 | OFI |
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| r1l1 | Gorica | 1-4 | Roma |
|
| Thursday, 21 September 2000 |
| r1l2 | Hertha BSC Berlin | 2-0 | Zimbru | 4-1 |
| r1l2 | Kaiserslautern | 0-1 | Bohemians | 3-2 |
| Tuesday, 26 September 2000 |
| r1l2 | TSV München 1860 | 1-0 | FK Drnovice | 1-0 |
| r1l2 | GAK | 0-0 | 1.FC Košice* | 3-2 |
| r1l2 | Viborg | 1-0 | CSKA | 1-0, aet |
| r1l2 | Inter Bratislava | 2-1 | Roda JC | 4-1 |
| r1l2 | Bordeaux | 5-1 | Lierse | 5-1 |
| Thursday, 28 September 2000 |
| r1l2 | St.Gallen | 2-0 | Chelsea | 2-1 |
| r1l2 | Hearts | 3-2 | VfB Stuttgart | 3-3 |
| r1l2 | SV Werder Bremen | 6-0 | Antalyaspor | 6-2 |
| r1l2 | Fiorentina | 2-2 | Wacker Innsbruck | 3-5 |
| r1l2 | Nantes | 5-0 | Kryvbas* | 6-0 |
| r1l2 | Crvena Zvezda | 3-1 | Leicester City | 4-2 |
| r1l2 | Ajax | 3-0 | AA Gent | 9-0 |
| r1l2 | Udinese | 2-0 | Polonia Warszawa | 3-0 |
| r1l2 | Rijeka | 0-1 | Celta Vigo | 0-1, aet |
| r1l2 | Wisła Kraków | 4-1 | Zaragoza | 5-5, aet, p4-3 |
| r1l2 | Beitar Jerusalem | 3-3 | PAOK | 4-6 |
| r1l2 | Inter | 4-1 | Ruch Chorzów | 7-1 |
| r1l2 | AB | 0-2 | Slavia Praha | 0-5 |
| r1l2 | Liverpool | 0-0 | Rapid București | 1-0 |
| r1l2 | Feyenoord | 3-1 | Dunaferr | 4-1 |
| r1l2 | FC Porto | 1-0 | Partizan | 2-1 |
| r1l2 | Parma | 4-0 | Pobeda | 6-0 |
| r1l2 | Gaziantepspor | 3-4 | Alavés | 3-4 |
| r1l2 | Osijek | 0-0 | Brøndby | 2-1 |
| r1l2 | APOEL | 0-1 | Club Brugge | 0-3 |
| r1l2 | Benfica | 2-2 | Halmstad | 3-4 |
| r1l2 | HJK | 2-1 | Celtic | 2-3, aet |
| r1l2 | Racing Genk | 2-0 | FC Zürich | 4-1 |
| r1l2 | Rayo Vallecano | 1-1 | Molde | 2-1 |
| r1l2 | HB Køge | 1-1 | AIK | 2-1, aet |
| r1l2 | MTK | 0-1 | CSKA | 2-2 |
| r1l2 | Naftex | 0-0 | Lokomotiv | 2-4 |
| r1l2 | Boavista | 2-1 | Vorskla-Naftohaz | 4-2 |
| r1l2 | Maccabi Haifa | 2-1 | Vitesse | 2-4 |
| r1l2 | Slovan Liberec | 2-1 | IFK Norrköping | 4-3 |
| r1l2 | AEK | 2-0 | Vasas | 4-2 |
| r1l2 | Örgryte | 1-1 | SK Rapid Wien | 1-4 |
| r1l2 | Torpedo | 0-2 | Lausanne | 2-5 |
| r1l2 | Dinamo Zagreb | 1-1 | Slovan Bratislava | 4-1 |
| r1l2 | Amica Wronki | 2-0 | Alania | 5-0 |
| r1l2 | Iraklis | 1-0 | Gueugnon | 1-0 |
| r1l2 | Espanyol | 2-0 | Olimpija | 3-2 |
| r1l2 | Dinamo | 2-1 | Lillestrøm | 3-4 |
| r1l2 | OFI | 6-0 | Napredak Kruševac | 6-0 |
| r1l2 | Roma | 7-0 | Gorica | 11-1 |
| r1l2 | Brann | 4-4 | FC Basel | 6-7 |
