| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 449 | 1,225 | 2.72 | 215 | 47.88% | 135 | 30.07% | 99 | 22.05% |
| Group E | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Cincinnati | 31 | 19 | 8 | 4 | 53 | 35 | +18 | 65 | WWXX | 15 | 13 | 1 | 1 | 30 | 9 | 16 | 6 | 7 | 3 | 23 | 26 | ||
| 2 | Orlando City | 31 | 15 | 9 | 7 | 49 | 37 | +12 | 54 | WXLW | 16 | 8 | 5 | 3 | 28 | 17 | 15 | 7 | 4 | 4 | 21 | 20 | ||
| 3 | 3 | New England Revolution | 30 | 14 | 10 | 6 | 51 | 37 | +14 | 52 | WXLX | 15 | 11 | 4 | 0 | 34 | 13 | 15 | 3 | 6 | 6 | 17 | 24 | |
| 4 | Philadelphia Union | 31 | 14 | 9 | 8 | 53 | 37 | +16 | 51 | XXOX | 15 | 9 | 5 | 1 | 30 | 11 | 16 | 5 | 4 | 7 | 23 | 26 | ||
| 5 | 2 | Columbus Crew | 31 | 14 | 8 | 9 | 62 | 43 | +19 | 50 | XXWL | 16 | 11 | 4 | 1 | 39 | 13 | 15 | 3 | 4 | 8 | 23 | 30 | |
| 6 | 1 | Atlanta United | 31 | 13 | 10 | 8 | 61 | 47 | +14 | 49 | WXWX | 16 | 10 | 3 | 3 | 41 | 20 | 15 | 3 | 7 | 5 | 20 | 27 | |
| 7 | Nashville | 30 | 12 | 9 | 9 | 36 | 28 | +8 | 45 | OXWX | 14 | 8 | 4 | 2 | 22 | 9 | 16 | 4 | 5 | 7 | 14 | 19 | ||
| 8 | 4 | New York City | 32 | 8 | 14 | 10 | 34 | 37 | -3 | 38 | XWWO | 16 | 7 | 6 | 3 | 22 | 16 | 16 | 1 | 8 | 7 | 12 | 21 | |
| 9 | 1 | CF Montréal | 31 | 11 | 4 | 16 | 30 | 48 | -18 | 37 | LLXO | 15 | 9 | 2 | 4 | 21 | 10 | 16 | 2 | 2 | 12 | 9 | 38 | |
| 10 | 1 | D.C. United | 32 | 9 | 10 | 13 | 43 | 46 | -3 | 37 | XLXO | 16 | 5 | 6 | 5 | 29 | 23 | 16 | 4 | 4 | 8 | 14 | 23 | |
| 11 | Chicago Fire | 31 | 9 | 10 | 12 | 35 | 47 | -12 | 37 | WXLO | 15 | 5 | 7 | 3 | 22 | 19 | 16 | 4 | 3 | 9 | 13 | 28 | ||
| 12 | 2 | New York Red Bulls | 31 | 8 | 10 | 13 | 30 | 38 | -8 | 34 | LWXO | 16 | 6 | 5 | 5 | 18 | 17 | 15 | 2 | 5 | 8 | 12 | 21 | |
| 13 | 1 | Inter Miami | 30 | 9 | 6 | 15 | 38 | 46 | -8 | 33 | XXWL | 15 | 6 | 4 | 5 | 23 | 18 | 15 | 3 | 2 | 10 | 15 | 28 | |
| 14 | 1 | Charlotte FC | 30 | 7 | 12 | 11 | 37 | 50 | -13 | 33 | LLXO | 15 | 4 | 8 | 3 | 20 | 21 | 15 | 3 | 4 | 8 | 17 | 29 | |
| 15 | Toronto FC | 31 | 4 | 10 | 17 | 26 | 51 | -25 | 22 | LLLL | 16 | 4 | 6 | 6 | 19 | 20 | 15 | 0 | 4 | 11 | 7 | 31 | ||
| Group W | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | St. Louis CITY SC | 32 | 17 | 5 | 10 | 62 | 40 | +22 | 56 | WWOX | 16 | 11 | 2 | 3 | 41 | 15 | 16 | 6 | 3 | 7 | 21 | 25 | ||
| 2 | 1 | Seattle Sounders | 31 | 12 | 10 | 9 | 37 | 31 | +6 | 46 | OWXX | 15 | 6 | 5 | 4 | 17 | 10 | 16 | 6 | 5 | 5 | 20 | 21 | |
| 3 | 1 | Los Angeles | 30 | 12 | 9 | 9 | 44 | 34 | +10 | 45 | OOWL | 15 | 9 | 3 | 3 | 31 | 15 | 15 | 3 | 6 | 6 | 13 | 19 | |
| 4 | Houston Dynamo | 31 | 12 | 8 | 11 | 42 | 35 | +7 | 44 | OLWX | 16 | 10 | 4 | 2 | 31 | 10 | 15 | 2 | 4 | 9 | 11 | 25 | ||
| 5 | Real Salt Lake | 30 | 12 | 7 | 11 | 42 | 45 | -3 | 43 | WLLW | 16 | 6 | 4 | 6 | 23 | 24 | 14 | 6 | 3 | 5 | 19 | 21 | ||
| 6 | 1 | Vancouver Whitecaps | 31 | 11 | 10 | 10 | 51 | 47 | +4 | 43 | XXLL | 15 | 7 | 5 | 3 | 31 | 18 | 16 | 4 | 5 | 7 | 20 | 29 | |
| 7 | 1 | Portland Timbers | 32 | 11 | 10 | 11 | 44 | 51 | -7 | 43 | XWWW | 16 | 9 | 3 | 4 | 28 | 19 | 16 | 2 | 7 | 7 | 16 | 32 | |
| 8 | San Jose Earthquakes | 32 | 10 | 12 | 10 | 37 | 41 | -4 | 42 | XXLW | 16 | 8 | 6 | 2 | 24 | 15 | 16 | 2 | 6 | 8 | 13 | 26 | ||
| 9 | FC Dallas | 31 | 10 | 11 | 10 | 35 | 34 | +1 | 41 | OXXW | 15 | 7 | 5 | 3 | 21 | 14 | 16 | 3 | 6 | 7 | 14 | 20 | ||
| 10 | Sporting Kansas City | 32 | 10 | 8 | 14 | 42 | 48 | -6 | 38 | LWLW | 16 | 8 | 2 | 6 | 27 | 20 | 16 | 2 | 6 | 8 | 15 | 28 | ||
| 11 | Minnesota United | 31 | 9 | 11 | 11 | 39 | 41 | -2 | 38 | XLLL | 16 | 3 | 9 | 4 | 19 | 18 | 15 | 6 | 2 | 7 | 20 | 23 | ||
| 12 | Austin FC | 31 | 9 | 8 | 14 | 43 | 50 | -7 | 35 | LXXL | 15 | 6 | 4 | 5 | 23 | 18 | 16 | 3 | 4 | 9 | 20 | 32 | ||
| 13 | LA Galaxy | 30 | 8 | 11 | 11 | 45 | 54 | -9 | 35 | XXWL | 15 | 6 | 5 | 4 | 28 | 23 | 15 | 2 | 6 | 7 | 17 | 31 | ||
| 14 | Colorado Rapids | 31 | 5 | 11 | 15 | 24 | 47 | -23 | 26 | WXLL | 16 | 3 | 8 | 5 | 13 | 15 | 15 | 2 | 3 | 10 | 11 | 32 | ||
| 15 | Hany MUKHTAR (Nashville, 5p) | |
| Giorgos GIAKOUMAKIS (Atlanta United) | ||
| Luciano ACOSTA (FC Cincinnati, 6p) | ||
| 14 | +2 | Brian WHITE (Vancouver Whitecaps) |
| +1 | CUCHO (Columbus Crew, 5p) | |
| Denis BOUANGA (Los Angeles, 2p) | ||
| +1 | Christian BENTEKE (D.C. United, 1p) | |
| 13 | Dániel GAZDAG (Philadelphia Union, 11p) | |
| +1 | Facundo TORRES (Orlando City, 5p) | |
| Alan PULIDO (Sporting Kansas City, 3p) | ||
| 12 | Julián CARRANZA (Philadelphia Union) | |
| Cristian ESPINOZA (San Jose Earthquakes, 4p) | ||
| Jesús FERREIRA (FC Dallas, 1p) | ||
| 11 | +1 | Ryan GAULD (Vancouver Whitecaps, 6p) |
| 10 | Lucas ZELARAYÁN (Columbus Crew, 2p) | |
| +2 | João KLAUSS (St. Louis CITY SC) | |
| Sebastián DRIUSSI (Austin FC, 2p) | ||
| Thiago ALMADA (Atlanta United, 1p) | ||
| Jordan MORRIS (Seattle Sounders) | ||
| Nicholas GIOACCHINI (St. Louis CITY SC, 1p) | ||
| 9 | +1 | Karol ŚWIDERSKI (Charlotte FC, 1p) |
| Jeremy EBOBISSE (San Jose Earthquakes, 1p) | ||
| Amine BASSI (Houston Dynamo, 6p) | ||
| EVANDER da Silva (Portland Timbers, 1p) | ||
| +1 | Duncan McGUIRE (Orlando City) | |
| Carlos VELA (Los Angeles, 3p) | ||
| Leonardo CAMPANA (Inter Miami, 2p) | ||
| CARLES GIL de Pareja (New England Revolution, 2p) |
| Sunday, 24 September 2023 | |||||
| Orlando City | 1-1 | Inter Miami | |||
| 66 | McGuire | 52 | Ruiz | ||
| Austin FC | 3-3 | LA Galaxy | |||
| 11 | Ring | 45+2(p) | Riqui Puig | ||
| 45+6 | Finlay | 89 | Joveljić | ||
| 75 | Rigoni | 90+4 | Barrios | ||
| New York City | 3-0 | Toronto FC | |||
| 2 | Perea | ||||
| 45+4 | Jasson | ||||
| 54 | Fernández | ||||
| Wednesday, 27 September 2023 | |||||
| Colorado Rapids | 2-2 | Vancouver Whitecaps | |||
| 47 | Rubio | 11 | Laborda | ||
| 67 | Bassett | 78 | White | ||
| Philadelphia Union | 1-1 | FC Dallas | |||
| 25 | Sullivan | 36 | Velasco | ||
| Saturday, 30 September 2023 | |||||
| Houston Dynamo | 0-0 | FC Dallas | |||
| Colorado Rapids | 1-0 | Austin FC | |||
| 41 | Maxsø | ||||
| New York Red Bulls | 0-1 | Chicago Fire | |||
| 64 | Koutsias | ||||
| Columbus Crew | 1-1 | Philadelphia Union | |||
| 72(p) | Cucho | 50 | Harriel | ||
| New England Revolution | 2-1 | Charlotte FC | |||
| 64 | Buck | 84 | Świderski | ||
| 85 | Romney | ||||
| LA Galaxy | 3-3 | Portland Timbers | |||
| 10 | Zavaleta | 5 | Moreno | ||
| 43 | Douglas Costa | 38(og) | Zavaleta | ||
| 45+1 | Zavaleta | 76 | Mora | ||
| Vancouver Whitecaps | 2-2 | D.C. United | |||
| 2 | White | 11 | Benteke | ||
| 57(p) | Gauld | 62 | Klich | ||
| Toronto FC | 2-3 | FC Cincinnati | |||
| 39 | Osorio | 28 | Vázquez | ||
| 44 | Osorio | 35 | Vázquez | ||
| 72 | Boupendza | ||||
| Orlando City | 3-0 | CF Montréal | |||
| 19(og) | Sirois | ||||
| 50 | Þórhallsson | ||||
| 54 | Torres | ||||
| Minnesota United | 1-1 | San Jose Earthquakes | |||
| 56 | Pukki | 82 | Marie | ||
| Nashville | 0-0 | Seattle Sounders | |||
| Inter Miami | 1-1 | New York City | |||
| 90+5 | Avilés | 77 | Rodríguez | ||
| St. Louis CITY SC | 4-1 | Sporting Kansas City | |||
| 73 | Adeniran | 90+3 | Agada | ||
| 75 | Stroud | ||||
| 80 | Klauss | ||||
| 85 | Klauss | ||||