| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 233 | 597 | 2.56 | 115 | 49.36% | 65 | 27.90% | 53 | 22.75% |
| Group E | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Cincinnati | 16 | 12 | 3 | 1 | 26 | 15 | +11 | 39 | WWWW | 9 | 9 | 0 | 0 | 16 | 5 | 7 | 3 | 3 | 1 | 10 | 10 | ||
| 2 | Nashville | 16 | 9 | 4 | 3 | 24 | 11 | +13 | 31 | WWWW | 9 | 6 | 2 | 1 | 16 | 5 | 7 | 3 | 2 | 2 | 8 | 6 | ||
| 3 | Philadelphia Union | 16 | 9 | 3 | 4 | 27 | 15 | +12 | 30 | WWWW | 9 | 6 | 2 | 1 | 17 | 5 | 7 | 3 | 1 | 3 | 10 | 10 | ||
| 4 | New England Revolution | 16 | 7 | 6 | 3 | 25 | 20 | +5 | 27 | OXXL | 7 | 4 | 3 | 0 | 15 | 6 | 9 | 3 | 3 | 3 | 10 | 14 | ||
| 5 | Atlanta United | 17 | 6 | 7 | 4 | 32 | 28 | +4 | 25 | OXXX | 8 | 5 | 2 | 1 | 19 | 10 | 9 | 1 | 5 | 3 | 13 | 18 | ||
| 6 | Columbus Crew | 16 | 7 | 3 | 6 | 33 | 24 | +9 | 24 | WWLL | 9 | 6 | 2 | 1 | 25 | 10 | 7 | 1 | 1 | 5 | 8 | 14 | ||
| 7 | 1 | D.C. United | 17 | 6 | 5 | 6 | 24 | 21 | +3 | 23 | WXLW | 8 | 3 | 3 | 2 | 14 | 10 | 9 | 3 | 2 | 4 | 10 | 11 | |
| 8 | 1 | Orlando City | 15 | 6 | 5 | 4 | 20 | 17 | +3 | 23 | WXWX | 8 | 2 | 3 | 3 | 7 | 9 | 7 | 4 | 2 | 1 | 13 | 8 | |
| 9 | 2 | Charlotte FC | 17 | 6 | 3 | 8 | 22 | 30 | -8 | 21 | LLWL | 8 | 3 | 2 | 3 | 10 | 12 | 9 | 3 | 1 | 5 | 12 | 18 | |
| 10 | CF Montréal | 16 | 6 | 1 | 9 | 15 | 27 | -12 | 19 | LXWL | 6 | 5 | 0 | 1 | 10 | 3 | 10 | 1 | 1 | 8 | 5 | 24 | ||
| 11 | New York Red Bulls | 17 | 4 | 7 | 6 | 11 | 16 | -5 | 19 | LWLW | 8 | 3 | 3 | 2 | 7 | 8 | 9 | 1 | 4 | 4 | 4 | 8 | ||
| 12 | 1 | Toronto FC | 17 | 3 | 9 | 5 | 16 | 20 | -4 | 18 | XOWL | 9 | 3 | 5 | 1 | 10 | 8 | 8 | 0 | 4 | 4 | 6 | 12 | |
| 13 | 1 | New York City | 16 | 4 | 5 | 7 | 17 | 22 | -5 | 17 | OLLX | 8 | 4 | 2 | 2 | 12 | 11 | 8 | 0 | 3 | 5 | 5 | 11 | |
| 14 | 2 | Chicago Fire | 16 | 3 | 8 | 5 | 21 | 25 | -4 | 17 | LOXX | 8 | 2 | 6 | 0 | 13 | 11 | 8 | 1 | 2 | 5 | 8 | 14 | |
| 15 | Inter Miami | 16 | 5 | 0 | 11 | 15 | 21 | -6 | 15 | LLLL | 9 | 4 | 0 | 5 | 12 | 12 | 7 | 1 | 0 | 6 | 3 | 9 | ||
| Group W | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | St. Louis CITY SC | 15 | 9 | 1 | 5 | 32 | 16 | +16 | 28 | LWWW | 8 | 6 | 0 | 2 | 22 | 6 | 7 | 3 | 1 | 3 | 10 | 10 | |
| 2 | 1 | Seattle Sounders | 17 | 8 | 3 | 6 | 21 | 14 | +7 | 27 | OLWL | 10 | 5 | 2 | 3 | 13 | 5 | 7 | 3 | 1 | 3 | 8 | 9 | |
| 3 | Los Angeles | 13 | 7 | 5 | 1 | 23 | 10 | +13 | 26 | OWXW | 7 | 5 | 2 | 0 | 15 | 5 | 6 | 2 | 3 | 1 | 8 | 5 | ||
| 4 | FC Dallas | 17 | 7 | 5 | 5 | 21 | 18 | +3 | 26 | WLLX | 9 | 5 | 2 | 2 | 14 | 9 | 8 | 2 | 3 | 3 | 7 | 9 | ||
| 5 | San Jose Earthquakes | 16 | 6 | 5 | 5 | 19 | 19 | +0 | 23 | OWXL | 7 | 5 | 2 | 0 | 11 | 4 | 9 | 1 | 3 | 5 | 8 | 15 | ||
| 6 | Vancouver Whitecaps | 16 | 5 | 6 | 5 | 26 | 20 | +6 | 21 | XWLW | 9 | 5 | 3 | 1 | 20 | 8 | 7 | 0 | 3 | 4 | 6 | 12 | ||
| 7 | Minnesota United | 16 | 5 | 5 | 6 | 15 | 18 | -3 | 20 | XLXW | 7 | 1 | 5 | 1 | 6 | 6 | 9 | 4 | 0 | 5 | 9 | 12 | ||
| 8 | Austin FC | 16 | 5 | 4 | 7 | 17 | 23 | -6 | 19 | LWLW | 9 | 3 | 3 | 3 | 10 | 10 | 7 | 2 | 1 | 4 | 7 | 13 | ||
| 9 | 3 | Real Salt Lake | 16 | 5 | 4 | 7 | 18 | 27 | -9 | 19 | WLXW | 8 | 2 | 2 | 4 | 9 | 14 | 8 | 3 | 2 | 3 | 9 | 13 | |
| 10 | 1 | Houston Dynamo | 15 | 5 | 3 | 7 | 15 | 21 | -6 | 18 | LLWX | 7 | 5 | 1 | 1 | 9 | 2 | 8 | 0 | 2 | 6 | 6 | 19 | |
| 11 | 1 | Portland Timbers | 16 | 4 | 5 | 7 | 19 | 24 | -5 | 17 | OLLO | 7 | 3 | 2 | 2 | 11 | 7 | 9 | 1 | 3 | 5 | 8 | 17 | |
| 12 | 1 | Sporting Kansas City | 17 | 4 | 5 | 8 | 16 | 24 | -8 | 17 | XWWL | 7 | 3 | 1 | 3 | 10 | 9 | 10 | 1 | 4 | 5 | 6 | 15 | |
| 13 | 1 | Colorado Rapids | 17 | 2 | 7 | 8 | 14 | 25 | -11 | 13 | OLLL | 8 | 0 | 4 | 4 | 5 | 9 | 9 | 2 | 3 | 4 | 9 | 16 | |
| 14 | 1 | LA Galaxy | 15 | 3 | 3 | 9 | 13 | 26 | -13 | 12 | WLLL | 7 | 2 | 1 | 4 | 9 | 11 | 8 | 1 | 2 | 5 | 4 | 15 | |
| 10 | +1 | Hany MUKHTAR (Nashville, 3p) |
| +1 | Jesús FERREIRA (FC Dallas) | |
| Denis BOUANGA (Los Angeles, 1p) | ||
| 9 | +2 | Julián CARRANZA (Philadelphia Union) |
| Giorgos GIAKOUMAKIS (Atlanta United) | ||
| Jordan MORRIS (Seattle Sounders) | ||
| 8 | Cristian ESPINOZA (San Jose Earthquakes, 3p) | |
| +1 | Christian BENTEKE (D.C. United) | |
| 7 | Dániel GAZDAG (Philadelphia Union, 6p) | |
| Lucas ZELARAYÁN (Columbus Crew, 2p) | ||
| Thiago ALMADA (Atlanta United, 1p) | ||
| +1 | Luciano ACOSTA (FC Cincinnati, 2p) | |
| 6 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) | |
| Amine BASSI (Houston Dynamo, 4p) | ||
| Brian WHITE (Vancouver Whitecaps) | ||
| +1 | Mikael UHRE (Philadelphia Union) | |
| 5 | Bobby WOOD (New England Revolution) | |
| +1 | Karol ŚWIDERSKI (Charlotte FC, 1p) | |
| João KLAUSS (St. Louis CITY SC) | ||
| +1 | Eduard LÖWEN (St. Louis CITY SC, 3p) | |
| Jon GALLAGHER (Austin FC) | ||
| CARLES GIL de Pareja (New England Revolution, 1p) | ||
| +2 | Christian RAMIREZ (Columbus Crew) | |
| +1 | Nicholas GIOACCHINI (St. Louis CITY SC, 1p) |
| Saturday, 3 June 2023 | |||||
| FC Dallas | 1-2 | Nashville | |||
| 25 | Obrian | 9(og) | Norris | ||
| 77 | Mukhtar | ||||
| Colorado Rapids | 0-0 | San Jose Earthquakes | |||
| New York Red Bulls | 0-3 | Orlando City | |||
| 18 | Angulo | ||||
| 52(p) | Torres | ||||
| 72 | Torres | ||||
| Columbus Crew | 4-2 | Charlotte FC | |||
| 5 | Ramirez | 56 | Świderski | ||
| 21 | Arfsten | 58 | Meram | ||
| 43 | Cucho | ||||
| 59 | Ramirez | ||||
| Vancouver Whitecaps | 1-1 | Sporting Kansas City | |||
| 88(p) | Gauld | 20 | Pulido | ||
| Seattle Sounders | 0-0 | Portland Timbers | |||
| Philadelphia Union | 3-0 | CF Montréal | |||
| 12 | Carranza | ||||
| 36 | Uhre | ||||
| 61 | Carranza | ||||
| Minnesota United | 1-1 | Toronto FC | |||
| 89 | Arriaga | 58 | Insigne | ||
| Austin FC | 1-2 | Real Salt Lake | |||
| 90+2 | Cascante | 15 | Rubin | ||
| 81 | Rubin | ||||
| New York City | 0-0 | New England Revolution | |||
| FC Cincinnati | 1-0 | Chicago Fire | |||
| 83 | Acosta | ||||
| Inter Miami | 1-2 | D.C. United | |||
| 90+2 | Fray | 76 | Pines | ||
| 90 | Benteke | ||||
| St. Louis CITY SC | 3-0 | Houston Dynamo | |||
| 9(p) | Löwen | ||||
| 51 | Ostrák | ||||
| 83(p) | Gioacchini | ||||
| Wednesday, 7 June 2023 | |||||
| FC Dallas | 2-0 | St. Louis CITY SC | |||
| 80 | Ferreira | ||||
| 89 | Farfan | ||||
| Completion of previously abandoned game. 40 minutes played. | |||||
| Los Angeles | 0-0 | Atlanta United | |||