| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 405 | 1,089 | 2.68 | 199 | 49.14% | 115 | 28.40% | 91 | 22.47% |
| Group E | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Cincinnati | 28 | 17 | 7 | 4 | 46 | 32 | +14 | 58 | XLWW | 14 | 12 | 1 | 1 | 27 | 9 | 14 | 5 | 6 | 3 | 19 | 23 | ||
| 2 | 1 | Orlando City | 28 | 14 | 8 | 6 | 45 | 34 | +11 | 50 | WWXW | 14 | 7 | 4 | 3 | 24 | 16 | 14 | 7 | 4 | 3 | 21 | 18 | |
| 3 | 1 | New England Revolution | 28 | 13 | 9 | 6 | 47 | 34 | +13 | 48 | LXXW | 14 | 10 | 4 | 0 | 32 | 12 | 14 | 3 | 5 | 6 | 15 | 22 | |
| 4 | 1 | Philadelphia Union | 27 | 14 | 5 | 8 | 49 | 33 | +16 | 47 | XWLW | 13 | 9 | 3 | 1 | 29 | 10 | 14 | 5 | 2 | 7 | 20 | 23 | |
| 5 | 1 | Columbus Crew | 28 | 13 | 6 | 9 | 57 | 41 | +16 | 45 | LWLW | 14 | 10 | 3 | 1 | 35 | 12 | 14 | 3 | 3 | 8 | 22 | 29 | |
| 6 | Atlanta United | 29 | 12 | 9 | 8 | 56 | 45 | +11 | 45 | WXLW | 15 | 9 | 3 | 3 | 37 | 19 | 14 | 3 | 6 | 5 | 19 | 26 | ||
| 7 | Nashville | 27 | 11 | 7 | 9 | 32 | 27 | +5 | 40 | XOLL | 13 | 8 | 3 | 2 | 22 | 9 | 14 | 3 | 4 | 7 | 10 | 18 | ||
| 8 | CF Montréal | 28 | 11 | 3 | 14 | 28 | 40 | -12 | 36 | OLLW | 14 | 9 | 1 | 4 | 20 | 9 | 14 | 2 | 2 | 10 | 8 | 31 | ||
| 9 | D.C. United | 29 | 9 | 8 | 12 | 37 | 38 | -1 | 35 | OOWL | 14 | 5 | 5 | 4 | 25 | 17 | 15 | 4 | 3 | 8 | 12 | 21 | ||
| 10 | Chicago Fire | 28 | 8 | 9 | 11 | 32 | 42 | -10 | 33 | OLLL | 14 | 5 | 6 | 3 | 20 | 17 | 14 | 3 | 3 | 8 | 12 | 25 | ||
| 11 | Charlotte FC | 27 | 7 | 11 | 9 | 34 | 43 | -9 | 32 | OXXW | 14 | 4 | 7 | 3 | 18 | 19 | 13 | 3 | 4 | 6 | 16 | 24 | ||
| 12 | New York City | 29 | 6 | 13 | 10 | 28 | 36 | -8 | 31 | OXWL | 14 | 5 | 6 | 3 | 17 | 16 | 15 | 1 | 7 | 7 | 11 | 20 | ||
| 13 | New York Red Bulls | 28 | 7 | 9 | 12 | 24 | 33 | -9 | 30 | OLLL | 14 | 6 | 4 | 4 | 17 | 15 | 14 | 1 | 5 | 8 | 7 | 18 | ||
| 14 | Inter Miami | 27 | 8 | 4 | 15 | 32 | 44 | -12 | 28 | LWWO | 13 | 5 | 3 | 5 | 18 | 17 | 14 | 3 | 1 | 10 | 14 | 27 | ||
| 15 | Toronto FC | 28 | 4 | 10 | 14 | 24 | 41 | -17 | 22 | LWLL | 15 | 4 | 6 | 5 | 17 | 17 | 13 | 0 | 4 | 9 | 7 | 24 | ||
| Group W | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | St. Louis CITY SC | 29 | 15 | 4 | 10 | 56 | 38 | +18 | 49 | XXLW | 14 | 10 | 1 | 3 | 37 | 14 | 15 | 5 | 3 | 7 | 19 | 24 | ||
| 2 | 1 | Los Angeles | 28 | 12 | 7 | 9 | 44 | 34 | +10 | 43 | WLLL | 15 | 9 | 3 | 3 | 31 | 15 | 13 | 3 | 4 | 6 | 13 | 19 | |
| 3 | 1 | Seattle Sounders | 29 | 11 | 9 | 9 | 35 | 30 | +5 | 42 | XXWX | 15 | 6 | 5 | 4 | 17 | 10 | 14 | 5 | 4 | 5 | 18 | 20 | |
| 4 | 2 | Vancouver Whitecaps | 27 | 11 | 8 | 8 | 45 | 37 | +8 | 41 | WXWW | 14 | 7 | 4 | 3 | 29 | 16 | 13 | 4 | 4 | 5 | 16 | 21 | |
| 5 | Houston Dynamo | 28 | 11 | 7 | 10 | 37 | 32 | +5 | 40 | XOWW | 14 | 9 | 3 | 2 | 27 | 9 | 14 | 2 | 4 | 8 | 10 | 23 | ||
| 6 | 2 | Real Salt Lake | 28 | 11 | 7 | 10 | 39 | 41 | -2 | 40 | LWLL | 14 | 5 | 4 | 5 | 20 | 20 | 14 | 6 | 3 | 5 | 19 | 21 | |
| 7 | 1 | San Jose Earthquakes | 29 | 10 | 10 | 9 | 34 | 37 | -3 | 40 | WOXL | 15 | 8 | 5 | 2 | 23 | 14 | 14 | 2 | 5 | 7 | 11 | 23 | |
| 8 | 1 | Minnesota United | 28 | 9 | 10 | 9 | 34 | 34 | +0 | 37 | LXXW | 14 | 3 | 8 | 3 | 17 | 15 | 14 | 6 | 2 | 6 | 17 | 19 | |
| 9 | 2 | Sporting Kansas City | 29 | 9 | 8 | 12 | 39 | 40 | -1 | 35 | WLWW | 14 | 7 | 2 | 5 | 25 | 16 | 15 | 2 | 6 | 7 | 14 | 24 | |
| 10 | 1 | FC Dallas | 27 | 9 | 8 | 10 | 30 | 31 | -1 | 35 | XXLW | 14 | 7 | 4 | 3 | 20 | 13 | 13 | 2 | 4 | 7 | 10 | 18 | |
| 11 | 1 | Austin FC | 27 | 9 | 6 | 12 | 38 | 43 | -5 | 33 | XLLL | 13 | 6 | 3 | 4 | 19 | 13 | 14 | 3 | 3 | 8 | 19 | 30 | |
| 12 | Portland Timbers | 28 | 8 | 9 | 11 | 34 | 44 | -10 | 33 | WXWL | 14 | 7 | 3 | 4 | 23 | 16 | 14 | 1 | 6 | 7 | 11 | 28 | ||
| 13 | LA Galaxy | 27 | 7 | 9 | 11 | 35 | 45 | -10 | 30 | LXOW | 13 | 5 | 4 | 4 | 21 | 17 | 14 | 2 | 5 | 7 | 14 | 28 | ||
| 14 | Colorado Rapids | 27 | 4 | 10 | 13 | 18 | 40 | -22 | 22 | WLLL | 13 | 2 | 7 | 4 | 9 | 11 | 14 | 2 | 3 | 9 | 9 | 29 | ||
| 14 | Hany MUKHTAR (Nashville, 5p) | |
| +1 | Giorgos GIAKOUMAKIS (Atlanta United) | |
| +2 | Denis BOUANGA (Los Angeles, 2p) | |
| 13 | +1 | Alan PULIDO (Sporting Kansas City, 3p) |
| Luciano ACOSTA (FC Cincinnati, 5p) | ||
| 12 | +1 | Julián CARRANZA (Philadelphia Union) |
| +2 | Dániel GAZDAG (Philadelphia Union, 10p) | |
| Cristian ESPINOZA (San Jose Earthquakes, 4p) | ||
| +1 | Facundo TORRES (Orlando City, 5p) | |
| 11 | +1 | Brian WHITE (Vancouver Whitecaps) |
| 10 | Lucas ZELARAYÁN (Columbus Crew, 2p) | |
| Jesús FERREIRA (FC Dallas) | ||
| Ryan GAULD (Vancouver Whitecaps, 5p) | ||
| Jordan MORRIS (Seattle Sounders) | ||
| +1 | CUCHO (Columbus Crew, 2p) | |
| Christian BENTEKE (D.C. United) | ||
| Nicholas GIOACCHINI (St. Louis CITY SC, 1p) | ||
| 9 | +1 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) |
| Amine BASSI (Houston Dynamo, 6p) | ||
| Carlos VELA (Los Angeles, 3p) | ||
| Thiago ALMADA (Atlanta United, 1p) | ||
| +5 | Leonardo CAMPANA (Inter Miami, 2p) |
| Sunday, 3 September 2023 | |||||
| Philadelphia Union | 4-1 | New York Red Bulls | |||
| 29 | Glesnes | 11 | Fernandez | ||
| 57 | Lowe | ||||
| 58 | Carranza | ||||
| 76 | Gazdag | ||||
| Los Angeles | 1-3 | Inter Miami | |||
| 90 | Hollingshead | 14 | Farías | ||
| 51 | Jordi Alba | ||||
| 83 | Campana | ||||
| Saturday, 9 September 2023 | |||||
| D.C. United | 0-0 | San Jose Earthquakes | |||
| Portland Timbers | 2-0 | Los Angeles | |||
| 28 | Mabiala | ||||
| 53 | Bravo | ||||
| Minnesota United | 1-1 | New England Revolution | |||
| 90+3 | Fragapane | 38 | Carles Gil | ||
| Inter Miami | 3-2 | Sporting Kansas City | |||
| 25(p) | Campana | 9 | Sallói | ||
| 45 | Campana | 78 | Pulido | ||
| 60 | Farías | ||||
| Sunday, 10 September 2023 | |||||
| LA Galaxy | 2-2 | St. Louis CITY SC | |||
| 53(p) | Riqui Puig | 4 | Adeniran | ||
| 82 | Sharp | 28 | Klauss | ||
| Saturday, 16 September 2023 | |||||
| FC Dallas | 1-1 | Seattle Sounders | |||
| 15 | Obrian | 57 | Roldán | ||
| Houston Dynamo | 1-1 | St. Louis CITY SC | |||
| 42 | Baird | 87 | Klauss | ||
| Colorado Rapids | 2-1 | New England Revolution | |||
| 48 | Bassett | 90+2 | González | ||
| 62 | Harris | ||||
| CF Montréal | 0-0 | Chicago Fire | |||
| Toronto FC | 1-2 | Vancouver Whitecaps | |||
| 50 | Kerr | 56 | Blackmon | ||
| 66 | White | ||||
| San Jose Earthquakes | 2-1 | Real Salt Lake | |||
| 2 | Ebobisse | 44 | Arango | ||
| 15 | Tonhão | ||||
| Orlando City | 4-3 | Columbus Crew | |||
| 48 | Ojeda | 16 | Gressel | ||
| 73 | Torres | 56 | Rossi | ||
| 86 | Enrique | 68 | Cucho | ||
| 90+7 | Enrique | ||||
| Philadelphia Union | 2-2 | FC Cincinnati | |||
| 23 | Martínez | 49 | Boupendza | ||
| 37(p) | Gazdag | 76 | Vázquez | ||
| Minnesota United | 0-1 | Sporting Kansas City | |||
| 84 | Kinda | ||||
| Los Angeles | 4-2 | LA Galaxy | |||
| 24 | Bouanga | 25 | Sharp | ||
| 33 | Hollingshead | 59 | Yoshida | ||
| 75 | Bouanga | ||||
| 84 | Tillman | ||||
| New York City | 0-0 | New York Red Bulls | |||
| Atlanta United | 5-2 | Inter Miami | |||
| 36 | Muyumba | 25 | Campana | ||
| 41(og) | Miller | 53(p) | Campana | ||
| 44 | Lennon | ||||
| 76 | Giakoumakis | ||||
| 89 | Wolff | ||||
| Charlotte FC | 0-0 | D.C. United | |||