| ROUND | Q1 | R1 | R3 | QF | SF | F | ||||||
| l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | |
| Season archive |
| Tuesday, 5 August 2008 | ||||||
| r1l1 |  Independiente | 2-1 | Estudiantes (LP) | |||
| Wednesday, 6 August 2008 | ||||||
| r1l1 | Argentinos Juniors | 0-0 | San Lorenzo | |||
| Tuesday, 12 August 2008 | ||||||
| r1l1 |  Athlético-PR | 0-0 | São Paulo | |||
| Wednesday, 13 August 2008 | ||||||
| r1l1 | Vasco da Gama | 3-1 | Palmeiras | |||
| r1l1 | Internacional | 1-1 | Grêmio | |||
| Thursday, 14 August 2008 | ||||||
| r1l1 | Botafogo | 3-1 | Atlético-MG | |||
| r1l1 |  América | 2-0 | Cali | |||
| r1l1 |  LDU Quito | 4-2 | Bolívar | |||
| Tuesday, 19 August 2008 | ||||||
| r1l1 |  Defensor | 2-1 | Libertad | |||
| r1l1 | Arsenal | 4-0 | Motagua | |||
| Wednesday, 20 August 2008 | ||||||
| r1l2 | Estudiantes (LP) | 2-1 | Independiente | 3-3, p5-3 | ||
| Thursday, 21 August 2008 | ||||||
| r1l2 | San Lorenzo | 0-2 | Argentinos Juniors | 0-2 | ||
| Tuesday, 26 August 2008 | ||||||
| r1l1 |  Chiapas FC | 3-1 | Deportivo Quito | |||
| r1l2 | Libertad | 3-3 | Defensor | 4-5 | ||
| Wednesday, 27 August 2008 | ||||||
| r1l1 |  Aragua | 1-2 | Guadalajara | |||
| r1l2 | São Paulo | 0-0 | Athlético-PR | 0-0, aet, p3-4 | ||
| r1l2 | Atlético-MG | 2-5 | Botafogo | 3-8 | ||
| Thursday, 28 August 2008 | ||||||
| r1l1 |  Universidad Católica | 4-0 | Olimpia | |||
| r1l2 | Grêmio | 2-2 | Internacional | 3-3 | ||
| Thursday, 4 September 2008 | ||||||
| r1l1 | Ñublense | 1-0 | Sport Áncash | |||
| r1l2 | Motagua | 1-2 | Arsenal | 1-6 | ||
| Tuesday, 16 September 2008 | ||||||
| r1l2 | Cali | 1-0 | América | 1-2 | ||
| r1l2 | Sport Áncash | 4-0 | Ñublense | 4-1 | ||
| Wednesday, 17 September 2008 | ||||||
| r1l2 | Palmeiras | 3-0 | Vasco da Gama | 4-3 | ||
| r1l2 | Olimpia | 2-2 | Universidad Católica | 2-6 | ||
| r1l2 | Guadalajara | 1-1 | Aragua | 3-2 | ||
| r1l2 | Deportivo Quito | 3-2 | Chiapas FC | 4-5 | ||
| Thursday, 18 September 2008 | ||||||
| r1l2 | Bolívar | 2-1 | LDU Quito | 4-5 | ||
| 3 | +3 | CARLOS ALBERTO Gomes (Botafogo) |
| +3 | Juan SAMUDIO (Libertad, 1p) | |
| 2 | +2 | Julio GUTIÉRREZ (Universidad Católica) |
| +2 | Heatkliff CASTILLO (Aragua, 1p) | |
| +2 | Luciano LEGUIZAMÓN (Arsenal, 1p) | |
| +2 | Israel MARTINEZ (Chiapas FC) | |
| +2 | LÚCIO FLÁVIO dos Santos (Botafogo) | |
| +2 | THIAGO dos Santos CUNHA (Palmeiras) | |
| +2 | Reinaldo NAVIA (LDU Quito) | |
| +2 | Sergio SANTANA (Guadalajara) | |
| +2 | Renato RAMOS (Bolívar) | |
| +2 | Leonel NÚÑEZ (Independiente) | |
| +2 | Diego DE SOUZA (Defensor) | |
| +2 | LENÍLSON Batista (Atlético-MG) | |
| +2 | Jaison IBARROLA (Universidad Católica) |
