| ROUND | Q3 | Q4 | R1 | R2 | R3 | QF | SF | F | |||||||||||
| l1 | l2 | l1 | l2 | r1 | r2 | r3 | r4 | r5 | r6 | l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | ||
| Season archive |
| Group A | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Lyon | 3 | 3 | 0 | 0 | 9 | 3 | +6 | 9 | WWW- | ||
| 2 | Sparta Praha | 3 | 1 | 1 | 1 | 4 | 4 | +0 | 4 | LWO- | ||
| 3 | 1 | Rangers | 3 | 1 | 0 | 2 | 2 | 3 | -1 | 3 | WLL- | |
| 4 | 1 | Brøndby | 3 | 0 | 1 | 2 | 0 | 5 | -5 | 1 | LLO- | |
| Thursday, 21 October 2021 | |||||
| 3 |  Rangers | 2-0 | Brøndby | ||
| 18 | Balogun | ||||
| 30 | Roofe | ||||
| 3 |  Sparta Praha | 3-4 | Lyon | ||
| 4 | Haraslín | 42 | Toko Ekambi | ||
| 19 | Haraslín | 53 | Aouar | ||
| 90 | Krejčí | 67 | Lucas Paquetá | ||
| 88 | Toko Ekambi | ||||
| Group B | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Monaco | 3 | 2 | 1 | 0 | 4 | 2 | +2 | 7 | WXW- | ||
| 2 | 1 | Real Sociedad | 3 | 1 | 2 | 0 | 4 | 3 | +1 | 5 | WXX- | |
| 3 | 1 | PSV | 3 | 1 | 1 | 1 | 7 | 5 | +2 | 4 | LWX- | |
| 4 | SK Sturm Graz | 3 | 0 | 0 | 3 | 1 | 6 | -5 | 0 | LLL- | ||
| Thursday, 21 October 2021 | |||||
| 3 |  PSV | 1-2 | Monaco | ||
| 59 | Gakpo | 20 | Boadu | ||
| 89 | Diop | ||||
| 3 |  SK Sturm Graz | 0-1 | Real Sociedad | ||
| 69 | Isak | ||||
| Group C | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Legia Warszawa | 3 | 2 | 0 | 1 | 2 | 3 | -1 | 6 | LWW- | ||
| 2 | 1 | Napoli | 3 | 1 | 1 | 1 | 7 | 5 | +2 | 4 | WLX- | |
| 3 | 1 | Leicester City | 3 | 1 | 1 | 1 | 6 | 6 | +0 | 4 | WLX- | |
| 4 | 2 | Spartak | 3 | 1 | 0 | 2 | 6 | 7 | -1 | 3 | LWL- | |
| Wednesday, 20 October 2021 | |||||
| 3 |  Spartak | 3-4 | Leicester City | ||
| 11 | Sobolev | 45 | Daka | ||
| 44 | Larsson | 48 | Daka | ||
| 86 | Sobolev | 54 | Daka | ||
| 79 | Daka | ||||
| Thursday, 21 October 2021 | |||||
| 3 |  Napoli | 3-0 | Legia Warszawa | ||
| 76 | Insigne | ||||
| 80 | Osimhen | ||||
| 90 | Politano | ||||
| Group D | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | 1 | Eintracht Frankfurt | 3 | 2 | 1 | 0 | 5 | 2 | +3 | 7 | WWX- | |
| 2 | 1 | Olympiakos | 3 | 2 | 0 | 1 | 6 | 4 | +2 | 6 | LWW- | |
| 3 | Fenerbahçe | 3 | 0 | 2 | 1 | 3 | 6 | -3 | 2 | XLX- | ||
| 4 | Antwerp | 3 | 0 | 1 | 2 | 3 | 5 | -2 | 1 | XLL- | ||
| Thursday, 21 October 2021 | |||||
| 3 |  Fenerbahçe | 2-2 | Antwerp | ||
| 21 | Valencia | 2 | Samatta | ||
| 45(p) | Valencia | 62 | Gerkens | ||
| 3 |  Eintracht Frankfurt | 3-1 | Olympiakos | ||
| 26(p) | Borré | 30(p) | El Arabi | ||
| 45 | Touré | ||||
| 59 | Kamada | ||||
| Group E | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Galatasaray | 3 | 2 | 1 | 0 | 2 | 0 | +2 | 7 | WOW- | ||
| 2 | Lazio | 3 | 1 | 1 | 1 | 2 | 1 | +1 | 4 | OWL- | ||
| 3 | Marseille | 3 | 0 | 3 | 0 | 1 | 1 | +0 | 3 | OOX- | ||
| 4 | Lokomotiv | 3 | 0 | 1 | 2 | 1 | 4 | -3 | 1 | LLX- | ||
| Thursday, 21 October 2021 | |||||
| 3 | Lazio | 0-0 | Marseille | ||
| 3 | Lokomotiv | 0-1 | Galatasaray | ||
| 82 | Aktürkoğlu | ||||
| Group F | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Crvena Zvezda | 3 | 2 | 1 | 0 | 4 | 2 | +2 | 7 | XWW- | ||
| 2 | Sporting Braga | 3 | 2 | 0 | 1 | 5 | 3 | +2 | 6 | WWL- | ||
| 3 | 1 | FC Midtjylland | 3 | 0 | 2 | 1 | 3 | 5 | -2 | 2 | XLX- | |
| 4 | 1 | Ludogorets | 3 | 0 | 1 | 2 | 1 | 3 | -2 | 1 | LLX- | |
| Thursday, 21 October 2021 | |||||
| 3 | FC Midtjylland | 1-1 | Crvena Zvezda | ||
| 78 | Dyhr | 58 | Ivanić | ||
| 3 |  Ludogorets | 0-1 | Sporting Braga | ||
| 7 | Horta | ||||
| Group G | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Bayer Leverkusen | 3 | 2 | 1 | 0 | 7 | 2 | +5 | 7 | XWW- | ||
| 2 | Real Betis | 3 | 2 | 1 | 0 | 8 | 5 | +3 | 7 | XWW- | ||
| 3 | Celtic | 3 | 1 | 0 | 2 | 5 | 8 | -3 | 3 | WLL- | ||
| 4 | Ferencváros | 3 | 0 | 0 | 3 | 2 | 7 | -5 | 0 | LLL- | ||
| Tuesday, 19 October 2021 | |||||
| 3 | Celtic | 2-0 | Ferencváros | ||
| 57 | Furuhashi | ||||
| 81(og) | Vécsei | ||||
| Thursday, 21 October 2021 | |||||
| 3 | Real Betis | 1-1 | Bayer Leverkusen | ||
| 75(p) | Borja Iglesias | 82 | Andrich | ||
| Group H | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | West Ham United | 3 | 3 | 0 | 0 | 7 | 0 | +7 | 9 | WWW- | ||
| 2 | Dinamo Zagreb | 3 | 1 | 0 | 2 | 4 | 4 | +0 | 3 | LWL- | ||
| 3 | 1 | SK Rapid Wien | 3 | 1 | 0 | 2 | 2 | 4 | -2 | 3 | WLL- | |
| 4 | 1 | Racing Genk | 3 | 1 | 0 | 2 | 1 | 6 | -5 | 3 | LLW- | |
| Thursday, 21 October 2021 | |||||
| 3 | West Ham United | 3-0 | Racing Genk | ||
| 45 | Dawson | ||||
| 57 | Diop | ||||
| 59 | Bowen | ||||
| 3 | SK Rapid Wien | 2-1 | Dinamo Zagreb | ||
| 9 | Grüll | 24 | Oršić | ||
| 34 | Hofmann | ||||
| 5 | +2 | Karl TOKO EKAMBI (Lyon) |
| 4 | +4 | Patson DAKA (Leicester City) |
| +1 | Victor OSIMHEN (Napoli) | |
| 3 | Wenderson GALENO (Sporting Braga, 1p) | |
| 2 | Giorgos MASOURAS (Olympiakos) | |
| JUANMI (Real Betis) | ||
| +1 | Youssef EL ARABI (Olympiakos, 1p) | |
| +2 | Lukás HARASLÍN (Sparta Praha) | |
| +2 | Enner VALENCIA (Fenerbahçe, 1p) | |
| +2 | Aleksandr SOBOLEV (Spartak) | |
| Bruno PETKOVIĆ (Dinamo Zagreb, 2p) | ||
| +1 | BORJA IGLESIAS Quintas (Real Betis, 1p) | |
| +1 | Cody GAKPO (PSV) | |
| Declan RICE (West Ham United) | ||
| +1 | Ricardo HORTA (Sporting Braga) | |
| Florian WIRTZ (Bayer Leverkusen) | ||
| +1 | Houssem AOUAR (Lyon) | |
| +1 | Alexander ISAK (Real Sociedad) | |
| Quincy PROMES (Spartak) | ||
| +1 | Mbwana SAMATTA (Antwerp) |
