Results| Wednesday, 12 January 2022 |
| r2l1 | Onisilos | 4-3 | Karmiotissa |
|
| r2l1 | Ermis | 1-1 | ENP |
|
| Tuesday, 18 January 2022 |
| r2l1 | AEK | 1-1 | PAEEK |
|
| Wednesday, 19 January 2022 |
| r2l1 | APOEL | 2-1 | Olympiakos |
|
| r2l1 | Pafos FC | 1-3 | Anorthosis |
|
| r2l2 | ENP | 5-0 | Ermis | 6-1 |
| r2l2 | Karmiotissa | 0-1 | Onisilos | 3-5 |
| Thursday, 20 January 2022 |
| r2l1 | PO Xylotympou | 0-5 | Omonia |
|
| Wednesday, 26 January 2022 |
| r2l1 | Apollon | 1-0 | AEL |
|
| r2l1 | Ethnikos Achna | 3-1 | Doxa |
|
| Tuesday, 1 February 2022 |
| r2l2 | Omonia | 2-1 | PO Xylotympou | 7-1 |
| Wednesday, 2 February 2022 |
| r2l2 | Olympiakos | 0-4 | APOEL | 1-6 |
| Thursday, 3 February 2022 |
| r2l2 | Anorthosis | 0-0 | Pafos FC | 3-1 |
| r2l2 | Doxa | 0-0 | Ethnikos Achna | 1-3 |
| Wednesday, 2 March 2022 |
| r2l2 | AEL | 2-0 | Apollon | 2-1, aet |
| r2l2 | PAEEK | 2-2 | AEK | 3-3 |
Kypello
