| ROUND | Q1 | Q2 | Q3 | R1 | R2 | QF | SF | F | |||||||||||
| l1 | l2 | l1 | l2 | l1 | l2 | r1 | r2 | r3 | r4 | r5 | r6 | l1 | l2 | l1 | l2 | l1 | l2 | ||
| Season archive |
| Tuesday, 22 February 2022 | ||||||
| q2l1 |  Millonarios | 1-2 | Fluminense | |||
| q2l1 |  Everton | 3-0 | Monagas | |||
| q2l1 |  Plaza Colonia | 2-0 | Strongest | |||
| Wednesday, 23 February 2022 | ||||||
| q2l1 | Bolívar | 1-1 | Universidad Católica | |||
| q2l1 | América-MG | 0-1 | Guaraní | |||
| q2l1 | Barcelona | 2-0 | Universitario | |||
| q2l1 | Audax Italiano | 1-0 | Estudiantes (LP) | |||
| Thursday, 24 February 2022 | ||||||
| q2l1 | Olimpia | 3-1 | Nacional | |||
| Tuesday, 1 March 2022 | ||||||
| q2l2 | Strongest | 3-0 | Plaza Colonia | 3-2 | ||
| q2l2 | Millonarios | 1-2 | Fluminense | 1-2 | ||
| q2l2 | Monagas | 1-0 | Everton | 1-3 | ||
| Wednesday, 2 March 2022 | ||||||
| q2l2 | Estudiantes (LP) | 2-0 | Audax Italiano | 2-1 | ||
| q2l2 | Guaraní | 2-3 | América-MG | 3-3 | ||
| q2l2 | Universitario | 0-1 | Barcelona | 0-3 | ||
| q2l2 | Universidad Católica | 2-0 | Bolívar | 3-1 | ||
| Thursday, 3 March 2022 | ||||||
| q2l2 | Nacional | 1-1 | Olimpia | 2-4 | ||
