Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 291 | 781 | 2.68 | 156 | 53.61% | 65 | 22.34% | 70 | 24.05% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Sporting Kansas City | 31 | 17 | 7 | 7 | 39 | 25 | +14 | 58 | WOWX | 16 | 9 | 4 | 3 | 20 | 11 | 15 | 8 | 3 | 4 | 19 | 14 | ||
| 2 | 1 | New York Red Bulls | 31 | 15 | 8 | 8 | 54 | 44 | +10 | 53 | WXLW | 15 | 11 | 3 | 1 | 34 | 16 | 16 | 4 | 5 | 7 | 20 | 28 | |
| 3 | 1 | Chicago Fire | 30 | 16 | 5 | 9 | 42 | 36 | +6 | 53 | LWWW | 15 | 11 | 2 | 2 | 25 | 14 | 15 | 5 | 3 | 7 | 17 | 22 | |
| 4 | D.C. United | 31 | 15 | 6 | 10 | 48 | 40 | +8 | 51 | XWWW | 16 | 11 | 4 | 1 | 34 | 15 | 15 | 4 | 2 | 9 | 14 | 25 | ||
| 5 | Houston Dynamo | 31 | 13 | 10 | 8 | 44 | 37 | +7 | 49 | WLXW | 15 | 10 | 5 | 0 | 27 | 10 | 16 | 3 | 5 | 8 | 17 | 27 | ||
| 6 | Columbus Crew | 31 | 14 | 6 | 11 | 39 | 39 | +0 | 48 | WLWL | 15 | 10 | 2 | 3 | 25 | 19 | 16 | 4 | 4 | 8 | 14 | 20 | ||
| 7 | Montréal Impact | 31 | 12 | 4 | 15 | 44 | 49 | -5 | 40 | OLLW | 16 | 10 | 3 | 3 | 31 | 18 | 15 | 2 | 1 | 12 | 13 | 31 | ||
| 8 | 1 | Philadelphia Union | 29 | 8 | 6 | 15 | 31 | 36 | -5 | 30 | LWLX | 15 | 6 | 2 | 7 | 21 | 17 | 14 | 2 | 4 | 8 | 10 | 19 | |
| 9 | 1 | New England Revolution | 31 | 7 | 8 | 16 | 37 | 43 | -6 | 29 | LXLW | 16 | 6 | 6 | 4 | 22 | 15 | 15 | 1 | 2 | 12 | 15 | 28 | |
| 10 | Toronto FC | 31 | 5 | 7 | 19 | 35 | 59 | -24 | 22 | LLXL | 15 | 3 | 4 | 8 | 15 | 24 | 16 | 2 | 3 | 11 | 20 | 35 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | San Jose Earthquakes | 31 | 18 | 7 | 6 | 65 | 39 | +26 | 61 | XWXW | 16 | 10 | 5 | 1 | 41 | 20 | 15 | 8 | 2 | 5 | 24 | 19 | ||
| 2 | 1 | Real Salt Lake | 31 | 16 | 4 | 11 | 44 | 34 | +10 | 52 | WWLW | 16 | 11 | 1 | 4 | 27 | 15 | 15 | 5 | 3 | 7 | 17 | 19 | |
| 3 | 1 | Seattle Sounders | 30 | 13 | 10 | 7 | 45 | 31 | +14 | 49 | OLXW | 14 | 9 | 1 | 4 | 21 | 10 | 16 | 4 | 9 | 3 | 24 | 21 | |
| 4 | 2 | LA Galaxy | 30 | 15 | 4 | 11 | 54 | 42 | +12 | 49 | WWWW | 15 | 9 | 1 | 5 | 29 | 18 | 15 | 6 | 3 | 6 | 25 | 24 | |
| 5 | Vancouver Whitecaps | 31 | 10 | 9 | 12 | 31 | 40 | -9 | 39 | OXLL | 15 | 7 | 6 | 2 | 21 | 16 | 16 | 3 | 3 | 10 | 10 | 24 | ||
| 6 | FC Dallas | 31 | 9 | 10 | 12 | 38 | 41 | -3 | 37 | XWXL | 16 | 6 | 7 | 3 | 19 | 14 | 15 | 3 | 3 | 9 | 19 | 27 | ||
| 7 | Colorado Rapids | 30 | 9 | 3 | 18 | 38 | 45 | -7 | 30 | XLWL | 14 | 7 | 2 | 5 | 25 | 14 | 16 | 2 | 1 | 13 | 13 | 31 | ||
| 8 | Portland Timbers | 31 | 7 | 9 | 15 | 32 | 52 | -20 | 30 | XLXX | 16 | 7 | 5 | 4 | 23 | 20 | 15 | 0 | 4 | 11 | 9 | 32 | ||
| 9 | Chivas USA | 30 | 7 | 7 | 16 | 21 | 49 | -28 | 28 | LLLL | 15 | 3 | 2 | 10 | 8 | 27 | 15 | 4 | 5 | 6 | 13 | 22 | ||
| 22 | Chris WONDOLOWSKI (San Jose Earthquakes) | |
| 17 | +3 | Álvaro SABORIO (Real Salt Lake) |
| 16 | +2 | Kenny COOPER (New York Red Bulls) |
| 14 | Robbie KEANE (LA Galaxy) | |
| +1 | Thierry HENRY (New York Red Bulls) | |
| 13 | Eddie JOHNSON (Seattle Sounders) | |
| +1 | Alan GORDON (San Jose Earthquakes) | |
| 12 | +1 | Chris PONTIUS (D.C. United) |
| Fredy MONTERO (Seattle Sounders) | ||
| 11 | Kei KAMARA (Sporting Kansas City) | |
| Will BRUIN (Houston Dynamo) | ||
| Saër SÈNE (New England Revolution) | ||
| 10 | +2 | Steven LENHART (San Jose Earthquakes) |
| 9 | Landon DONOVAN (LA Galaxy) | |
| Danny KOEVERMANS (Toronto FC) | ||
| Patrice BERNIER (Montréal Impact) | ||
| 8 | Simon DAWKINS (San Jose Earthquakes) | |
| Chris ROLFE (Chicago Fire) | ||
| +2 | Jairo ARRIETA (Columbus Crew) |
| Sunday, 23 September 2012 | |||||
| Philadelphia Union | 3-1 | Houston Dynamo | |||
| 28 | Adu | 44 | García | ||
| 50 | Adu | ||||
| 70 | Martínez | ||||
| D.C. United | 1-0 | Chivas USA | |||
| 64 | Boskovic | ||||
| Vancouver Whitecaps | 2-2 | Colorado Rapids | |||
| 64 | Rochat | 34 | Cummings | ||
| 68 | Miller | 86 | Smith | ||
| Friday, 28 September 2012 | |||||
| Sporting Kansas City | 2-0 | Chicago Fire | |||
| 11 | Zusi | ||||
| 90 | Zusi | ||||
| Saturday, 29 September 2012 | |||||
| Houston Dynamo | 2-0 | New England Revolution | |||
| 77 | Clark | ||||
| 90 | García | ||||
| Columbus Crew | 3-2 | Philadelphia Union | |||
| 44 | Arrieta | 65 | Cruz | ||
| 50 | Arrieta | 86 | McInerney | ||
| 87 | Mirosevic | ||||
| New York Red Bulls | 4-1 | Toronto FC | |||
| 13 | Holgersson | 6 | Johnson | ||
| 27 | Cooper | ||||
| 88 | Cooper | ||||
| 90 | Henry | ||||
| Vancouver Whitecaps | 0-0 | Seattle Sounders | |||
| Portland Timbers | 1-1 | D.C. United | |||
| 79 | Dike | 60 | Pontius | ||
| Chivas USA | 0-4 | Real Salt Lake | |||
| 8 | Saborio | ||||
| 11 | Saborio | ||||
| 65 | Saborio | ||||
| 81 | Paulo Araujo | ||||
| San Jose Earthquakes | 3-3 | FC Dallas | |||
| 24 | Gordon | 37 | Pérez | ||
| 82 | Lenhart | 72 | Pérez | ||
| 90 | Lenhart | 88 | Hedges | ||
