Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 174 | 475 | 2.72 | 90 | 51.72% | 46 | 26.44% | 38 | 21.84% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Columbus Crew | 25 | 14 | 5 | 6 | 44 | 31 | +13 | 47 | WXWW | 13 | 9 | 2 | 2 | 28 | 15 | 12 | 5 | 3 | 4 | 16 | 16 | ||
| 2 | New England Revolution | 25 | 12 | 6 | 7 | 36 | 34 | +2 | 42 | XWLX | 12 | 6 | 3 | 3 | 21 | 14 | 13 | 6 | 3 | 4 | 15 | 20 | ||
| 3 | Chicago Fire | 25 | 11 | 5 | 9 | 31 | 24 | +7 | 38 | LLWL | 12 | 5 | 2 | 5 | 13 | 12 | 13 | 6 | 3 | 4 | 18 | 12 | ||
| 4 | New York Red Bulls | 25 | 9 | 8 | 8 | 31 | 33 | -2 | 35 | LWLO | 12 | 8 | 3 | 1 | 22 | 11 | 13 | 1 | 5 | 7 | 9 | 22 | ||
| 5 | D.C. United | 25 | 10 | 3 | 12 | 41 | 43 | -2 | 33 | LXLO | 13 | 8 | 2 | 3 | 30 | 15 | 12 | 2 | 1 | 9 | 11 | 28 | ||
| 6 | Kansas City Wizards | 25 | 8 | 8 | 9 | 28 | 33 | -5 | 32 | WWLL | 12 | 7 | 3 | 2 | 17 | 12 | 13 | 1 | 5 | 7 | 11 | 21 | ||
| 7 | Toronto FC | 25 | 7 | 6 | 12 | 25 | 35 | -10 | 27 | LXLL | 13 | 5 | 6 | 2 | 13 | 9 | 12 | 2 | 0 | 10 | 12 | 26 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Houston Dynamo | 24 | 10 | 9 | 5 | 35 | 28 | +7 | 39 | XWWL | 12 | 8 | 3 | 1 | 25 | 13 | 12 | 2 | 6 | 4 | 10 | 15 | ||
| 2 | 2 | Chivas USA | 25 | 9 | 6 | 10 | 32 | 37 | -5 | 33 | WLWW | 12 | 6 | 3 | 3 | 17 | 11 | 13 | 3 | 3 | 7 | 15 | 26 | |
| 3 | Colorado Rapids | 25 | 9 | 4 | 12 | 33 | 33 | +0 | 31 | XWWL | 13 | 7 | 2 | 4 | 20 | 10 | 12 | 2 | 2 | 8 | 13 | 23 | ||
| 4 | 2 | Real Salt Lake | 25 | 8 | 7 | 10 | 30 | 32 | -2 | 31 | LLXW | 13 | 7 | 5 | 1 | 20 | 8 | 12 | 1 | 2 | 9 | 10 | 24 | |
| 5 | 1 | FC Dallas | 25 | 7 | 9 | 9 | 36 | 33 | +3 | 30 | WXLL | 12 | 4 | 4 | 4 | 17 | 16 | 13 | 3 | 5 | 5 | 19 | 17 | |
| 6 | 1 | LA Galaxy | 25 | 7 | 8 | 10 | 49 | 51 | -2 | 29 | WLXX | 13 | 5 | 4 | 4 | 30 | 23 | 12 | 2 | 4 | 6 | 19 | 28 | |
| 7 | 2 | San Jose Earthquakes | 24 | 7 | 8 | 9 | 24 | 28 | -4 | 29 | XWWO | 12 | 5 | 4 | 3 | 18 | 15 | 12 | 2 | 4 | 6 | 6 | 13 | |
| 19 | +3 | Landon DONOVAN (LA Galaxy, 3p) |
| 14 | Kenny COOPER (FC Dallas, 2p) | |
| 13 | Edson BUDDLE (LA Galaxy) | |
| 11 | Luciano EMILIO (D.C. United) | |
| 10 | Brian CHING (Houston Dynamo) | |
| +1 | Juan Pablo ÁNGEL (New York Red Bulls) | |
| Jaime MORENO (D.C. United, 4p) | ||
| 8 | Alejandro MORENO (Columbus Crew) | |
| 7 | Chad BARRETT (Toronto FC) | |
| Steve RALSTON (New England Revolution, 1p) | ||
| +2 | Jeff CUNNINGHAM (FC Dallas) | |
| 6 | +1 | Robbie ROGERS (Columbus Crew) |
| Guillermo BARROS SCHELOTTO (Columbus Crew, 4p) | ||
| Arturo ÁLVAREZ (San Jose Earthquakes) | ||
| Taylor TWELLMAN (New England Revolution) | ||
| Adam CRISTMAN (New England Revolution) | ||
| Dave VAN DEN BERGH (New York Red Bulls) |
| Thursday, 18 September 2008 | |||||
| Columbus Crew | 3-1 | New York Red Bulls | |||
| 41 | Hejduk | 21 | Ángel | ||
| 46 | Rogers | ||||
| 85 | Gaven | ||||
| Saturday, 20 September 2008 | |||||
| Kansas City Wizards | 2-0 | Toronto FC | |||
| 63(p) | Jewsbury | ||||
| 79 | Souter | ||||
| LA Galaxy | 5-2 | D.C. United | |||
| 23 | Donovan | 2 | McTavish | ||
| 35 | Donovan | 48 | Khumalo | ||
| 38 | Gordon | ||||
| 81 | Vagenas | ||||
| 90 | Donovan | ||||
| Real Salt Lake | 0-1 | Chivas USA | |||
| 72 | Eskandarian | ||||
| Colorado Rapids | 1-1 | New England Revolution | |||
| 42 | Clark | 50 | Mansally | ||
| Sunday, 21 September 2008 | |||||
| Chicago Fire | 1-4 | FC Dallas | |||
| 90 | McBride | 2 | Cunningham | ||
| 43 | Pitchkolan | ||||
| 45 | Guarda | ||||
| 61 | Cunningham | ||||
