| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 
| Season archive | 
| Games | Goals | H | D | A | ||||
| 76 | 215 | 2.82 | 40 | 52.63% | 15 | 19.74% | 21 | 27.63% | 
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 12 | 7 | 2 | 3 | 17 | 14 | +3 | 23 | WXWW | 6 | 3 | 1 | 2 | 9 | 7 | 6 | 4 | 1 | 1 | 8 | 7 | ||
| 2 | Chicago Fire | 10 | 6 | 1 | 3 | 20 | 8 | +12 | 19 | LWLW | 5 | 2 | 0 | 3 | 8 | 6 | 5 | 4 | 1 | 0 | 12 | 2 | ||
| 3 | Columbus Crew | 11 | 6 | 1 | 4 | 14 | 14 | +0 | 19 | LLLO | 6 | 4 | 0 | 2 | 9 | 7 | 5 | 2 | 1 | 2 | 5 | 7 | ||
| 4 | Toronto FC | 10 | 5 | 2 | 3 | 13 | 12 | +1 | 17 | WLWO | 6 | 4 | 2 | 0 | 7 | 1 | 4 | 1 | 0 | 3 | 6 | 11 | ||
| 5 | New York Red Bulls | 10 | 4 | 3 | 3 | 11 | 12 | -1 | 15 | WLLX | 6 | 3 | 2 | 1 | 8 | 7 | 4 | 1 | 1 | 2 | 3 | 5 | ||
| 6 | 1 | D.C. United | 12 | 4 | 1 | 7 | 17 | 23 | -6 | 13 | WXWL | 5 | 3 | 0 | 2 | 12 | 8 | 7 | 1 | 1 | 5 | 5 | 15 | |
| 7 | 1 | Kansas City Wizards | 10 | 3 | 3 | 4 | 10 | 13 | -3 | 12 | OLXL | 4 | 2 | 1 | 1 | 6 | 5 | 6 | 1 | 2 | 3 | 4 | 8 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy | 11 | 5 | 2 | 4 | 25 | 21 | +4 | 17 | WLWW | 7 | 4 | 1 | 2 | 18 | 12 | 4 | 1 | 1 | 2 | 7 | 9 | ||
| 2 | 3 | Colorado Rapids | 11 | 5 | 0 | 6 | 18 | 15 | +3 | 15 | LWLW | 6 | 4 | 0 | 2 | 11 | 5 | 5 | 1 | 0 | 4 | 7 | 10 | |
| 3 | 1 | Chivas USA | 11 | 4 | 2 | 5 | 17 | 18 | -1 | 14 | LWWW | 5 | 3 | 0 | 2 | 9 | 6 | 6 | 1 | 2 | 3 | 8 | 12 | |
| 4 | 1 | Houston Dynamo | 11 | 3 | 5 | 3 | 13 | 15 | -2 | 14 | WXLW | 4 | 2 | 2 | 0 | 6 | 4 | 7 | 1 | 3 | 3 | 7 | 11 | |
| 5 | 1 | FC Dallas | 12 | 3 | 4 | 5 | 16 | 19 | -3 | 13 | LLXW | 6 | 2 | 2 | 2 | 8 | 10 | 6 | 1 | 2 | 3 | 8 | 9 | |
| 6 | Real Salt Lake | 11 | 3 | 3 | 5 | 15 | 17 | -2 | 12 | OWLL | 6 | 3 | 3 | 0 | 12 | 5 | 5 | 0 | 0 | 5 | 3 | 12 | ||
| 7 | San Jose Earthquakes | 10 | 3 | 1 | 6 | 9 | 14 | -5 | 10 | WLWL | 4 | 1 | 1 | 2 | 4 | 5 | 6 | 2 | 0 | 4 | 5 | 9 | ||
| 9 | Landon DONOVAN (LA Galaxy, 2p) | |
| 6 | Kenny COOPER (FC Dallas) | |
| 5 | Robbie ROGERS (Columbus Crew) | |
| +1 | Edson BUDDLE (LA Galaxy) | |
| +1 | Chad BARRETT (Chicago Fire) | |
| +1 | Jaime MORENO (D.C. United, 3p) | |
| 4 | Cuauhtémoc BLANCO (Chicago Fire, 2p) | |
| Alejandro MORENO (Columbus Crew) | ||
| Danny DICHIO (Toronto FC) | ||
| Jesse MARSCH (Chivas USA) | ||
| Sacha KLJESTAN (Chivas USA) | ||
| David BECKHAM (LA Galaxy) | ||
| +1 | Dominic ODURO (FC Dallas) | |
| +1 | Luciano EMILIO (D.C. United) | |
| 3 | Kheli DUBE (New England Revolution) | |
| Claudio LÓPEZ (Kansas City Wizards, 1p) | ||
| Jimmy CONRAD (Kansas City Wizards) | ||
| John THORRINGTON (Chicago Fire) | ||
| +1 | Arturo ÁLVAREZ (FC Dallas) | |
| Edgar ESPÍNDOLA (Real Salt Lake) | ||
| Dwayne DE ROSARIO (Houston Dynamo, 1p) | ||
| Jorge VILLAFAÑA (Chivas USA) | ||
| +1 | Adam CRISTMAN (New England Revolution) | |
| Omar CUMMINGS (Colorado Rapids) | ||
| Alan GORDON (LA Galaxy) | ||
| Brian CHING (Houston Dynamo) | ||
| +1 | Tom McMANUS (Colorado Rapids) | |
| Kyle BECKERMAN (Real Salt Lake) | ||
| Marcelo GALLARDO (D.C. United) | ||
| Jozy ALTIDORE (New York Red Bulls) | 
| Sunday, 1 June 2008 | |||||
| Colorado Rapids | 2-1 | FC Dallas | |||
| 7 | Casey | 44 | Oduro | ||
| 72 | McManus | ||||
| Thursday, 5 June 2008 | |||||
| New York Red Bulls | 1-0 | Chivas USA | |||
| 75 | Ángel | ||||
| Friday, 6 June 2008 | |||||
| New England Revolution | 2-1 | FC Dallas | |||
| 5 | Cristman | 90 | Álvarez | ||
| 22(p) | Ralston | ||||
| Saturday, 7 June 2008 | |||||
| Columbus Crew | 0-2 | San Jose Earthquakes | |||
| 10 | Johnson | ||||
| 60 | Corrales | ||||
| LA Galaxy | 3-2 | Colorado Rapids | |||
| 4 | Álvaro | 73 | Clark | ||
| 32 | Buddle | 82 | Gomez | ||
| 50 | Allen | ||||
| Chicago Fire | 1-2 | D.C. United | |||
| 27 | Barrett | 63 | Moreno | ||
| 90 | Emilio | ||||
| Real Salt Lake | 0-0 | Kansas City Wizards | |||