| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 |
| 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 356 | 912 | 2.56 | 169 | 47.47% | 95 | 26.69% | 92 | 25.84% |
| 2000/01 | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Manchester United | 35 | 24 | 8 | 3 | 77 | 25 | +52 | 80 | WXWW | 18 | 15 | 2 | 1 | 49 | 11 | 17 | 9 | 6 | 2 | 28 | 14 | ||
| 2 | Arsenal | 35 | 19 | 9 | 7 | 59 | 34 | +25 | 66 | WWLW | 18 | 14 | 3 | 1 | 43 | 12 | 17 | 5 | 6 | 6 | 16 | 22 | ||
| 3 | 2 | Liverpool | 35 | 18 | 8 | 9 | 62 | 37 | +25 | 62 | WWWW | 17 | 12 | 3 | 2 | 35 | 12 | 18 | 6 | 5 | 7 | 27 | 25 | |
| 4 | Leeds United | 35 | 18 | 8 | 9 | 54 | 39 | +15 | 62 | WWWW | 17 | 9 | 3 | 5 | 27 | 19 | 18 | 9 | 5 | 4 | 27 | 20 | ||
| 5 | 2 | Ipswich Town | 36 | 19 | 5 | 12 | 54 | 40 | +14 | 62 | LWWW | 18 | 10 | 5 | 3 | 29 | 14 | 18 | 9 | 0 | 9 | 25 | 26 | |
| 6 | Chelsea | 35 | 15 | 9 | 11 | 62 | 41 | +21 | 54 | LLWW | 18 | 12 | 3 | 3 | 42 | 19 | 17 | 3 | 6 | 8 | 20 | 22 | ||
| 7 | 1 | Sunderland | 36 | 14 | 11 | 11 | 41 | 37 | +4 | 53 | WXLL | 18 | 8 | 7 | 3 | 21 | 14 | 18 | 6 | 4 | 8 | 20 | 23 | |
| 8 | 1 | Charlton Athletic | 36 | 14 | 10 | 12 | 48 | 50 | -2 | 52 | WWXL | 18 | 11 | 5 | 2 | 31 | 15 | 18 | 3 | 5 | 10 | 17 | 35 | |
| 9 | 2 | Aston Villa | 36 | 12 | 15 | 9 | 43 | 38 | +5 | 51 | OOXW | 18 | 7 | 8 | 3 | 24 | 18 | 18 | 5 | 7 | 6 | 19 | 20 | |
| 10 | 3 | Newcastle United | 35 | 13 | 8 | 14 | 41 | 47 | -6 | 47 | XWXW | 17 | 9 | 3 | 5 | 23 | 17 | 18 | 4 | 5 | 9 | 18 | 30 | |
| 11 | Tottenham Hotspur | 36 | 12 | 10 | 14 | 42 | 49 | -7 | 46 | OLLW | 18 | 10 | 6 | 2 | 28 | 15 | 18 | 2 | 4 | 12 | 14 | 34 | ||
| 12 | 2 | Southampton | 35 | 12 | 10 | 13 | 35 | 42 | -7 | 46 | XLOL | 17 | 9 | 2 | 6 | 22 | 19 | 18 | 3 | 8 | 7 | 13 | 23 | |
| 13 | 1 | Leicester City | 36 | 13 | 6 | 17 | 34 | 46 | -12 | 45 | LLLL | 18 | 9 | 4 | 5 | 24 | 21 | 18 | 4 | 2 | 12 | 10 | 25 | |
| 14 | 2 | Everton | 36 | 11 | 8 | 17 | 42 | 55 | -13 | 41 | WLLL | 18 | 6 | 7 | 5 | 27 | 25 | 18 | 5 | 1 | 12 | 15 | 30 | |
| 15 | 1 | West Ham United | 36 | 9 | 12 | 15 | 41 | 48 | -7 | 39 | LLLW | 18 | 5 | 6 | 7 | 21 | 20 | 18 | 4 | 6 | 8 | 20 | 28 | |
| 16 | 1 | Middlesbrough | 36 | 8 | 14 | 14 | 41 | 42 | -1 | 38 | LWLW | 18 | 3 | 7 | 8 | 16 | 22 | 18 | 5 | 7 | 6 | 25 | 20 | |
| 17 | Derby County | 36 | 9 | 11 | 16 | 35 | 58 | -23 | 38 | LLWL | 18 | 8 | 6 | 4 | 22 | 23 | 18 | 1 | 5 | 12 | 13 | 35 | ||
| 18 | 1 | Manchester City | 36 | 8 | 10 | 18 | 39 | 61 | -22 | 34 | WXWL | 18 | 4 | 3 | 11 | 19 | 29 | 18 | 4 | 7 | 7 | 20 | 32 | |
| 19 | 1 | Coventry City | 36 | 8 | 9 | 19 | 34 | 60 | -26 | 33 | LLWL | 18 | 4 | 6 | 8 | 14 | 23 | 18 | 4 | 3 | 11 | 20 | 37 | |
| 20 | Bradford City | 35 | 5 | 9 | 21 | 28 | 63 | -35 | 24 | LLWW | 18 | 4 | 6 | 8 | 19 | 28 | 17 | 1 | 3 | 13 | 9 | 35 | ||
| 19 | Marcus STEWART (Ipswich Town, 2p) | |
| 18 | Jimmy HASSELBAINK (Chelsea, 3p) | |
| 17 | Thierry HENRY (Arsenal, 1p) | |
| 16 | +1 | Mark VIDUKA (Leeds United) |
| 15 | Teddy SHERINGHAM (Manchester United, 1p) | |
| 14 | Emile HESKEY (Liverpool) | |
| 12 | Alen BOKSIC (Middlesbrough, 2p) | |
| 11 | James BEATTIE (Southampton) | |
| Ole SOLSKJÆR (Manchester United) | ||
| Gustavo POYET (Chelsea) | ||
| Jonatan JOHANSSON (Charlton Athletic) | ||
| Kevin PHILLIPS (Sunderland, 2p) | ||
| 10 | +1 | Michael OWEN (Liverpool) |
| Andrew COLE (Manchester United) | ||
| Eiður GUÐJOHNSEN (Chelsea) | ||
| Frédéric KANOUTÉ (West Ham United) | ||
| 9 | Ade AKINBIYI (Leicester City) | |
| +1 | Robbie KEANE (Leeds United, 1p) | |
| Gianfranco ZOLA (Chelsea) | ||
| Paulo WANCHOPE (Manchester City) | ||
| +1 | David BECKHAM (Manchester United, 1p) | |
| Paolo DI CANIO (West Ham United, 3p) | ||
| Les FERDINAND (Tottenham Hotspur) | ||
| Serhiy REBROV (Tottenham Hotspur, 1p) |
| Saturday, 28 April 2001 | |||||
| 36 | Coventry City | 0-2 | Liverpool | ||
| 83 | Hyypiä | ||||
| 86 | McAllister | ||||
| 36 | Everton | 2-1 | Bradford City | ||
| 47 | Ferguson | 3 | Myers | ||
| 64 | Alexandersson | ||||
| 36 | Leeds United | 2-0 | Chelsea | ||
| 86 | Keane | ||||
| 88 | Viduka | ||||
| 36 | Middlesbrough | 0-2 | Manchester United | ||
| 4 | Neville | ||||
| 84 | Beckham | ||||
| 36 | Newcastle United | 1-0 | Leicester City | ||
| 90 | Cort | ||||
| 36 | Southampton | 0-1 | Sunderland | ||
| 54 | Kilbane | ||||
| 36 | Tottenham Hotspur | 0-0 | Aston Villa | ||
| 36 | Derby County | 1-2 | Arsenal | ||
| 45 | Eranio | 21 | Kanu | ||
| 80 | Pirès | ||||
| 36 | Manchester City | 1-0 | West Ham United | ||
| 23(og) | Pearce | ||||
| Monday, 30 April 2001 | |||||
| 36 | Charlton Athletic | 2-1 | Ipswich Town | ||
| 12 | Svensson | 20 | Reuser | ||
| 57 | Rufus | ||||
| Tuesday, 1 May 2001 | |||||
| 21 | Bradford City | 0-2 | Liverpool | ||
| 47 | Owen | ||||
| 67 | McAllister | ||||
| 26 | Newcastle United | 1-1 | Southampton | ||
| 26 | Gallacher | 81 | Pahars | ||