| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 |
| 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 327 | 844 | 2.58 | 157 | 48.01% | 89 | 27.22% | 81 | 24.77% |
| 2000/01 | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Manchester United | 33 | 23 | 7 | 3 | 74 | 24 | +50 | 76 | WWLW | 17 | 15 | 1 | 1 | 48 | 10 | 16 | 8 | 6 | 2 | 26 | 14 | ||
| 2 | Arsenal | 33 | 17 | 9 | 7 | 53 | 32 | +21 | 60 | LWWO | 17 | 13 | 3 | 1 | 39 | 11 | 16 | 4 | 6 | 6 | 14 | 21 | ||
| 3 | Ipswich Town | 33 | 17 | 5 | 11 | 49 | 37 | +12 | 56 | WXWW | 17 | 9 | 5 | 3 | 27 | 14 | 16 | 8 | 0 | 8 | 22 | 23 | ||
| 4 | Leeds United | 33 | 16 | 8 | 9 | 50 | 39 | +11 | 56 | WWWW | 16 | 8 | 3 | 5 | 25 | 19 | 17 | 8 | 5 | 4 | 25 | 20 | ||
| 5 | 2 | Chelsea | 32 | 14 | 9 | 9 | 59 | 38 | +21 | 51 | WWWL | 17 | 12 | 3 | 2 | 42 | 18 | 15 | 2 | 6 | 7 | 17 | 20 | |
| 6 | 1 | Liverpool | 31 | 14 | 8 | 9 | 52 | 34 | +18 | 50 | LXWX | 16 | 11 | 3 | 2 | 32 | 11 | 15 | 3 | 5 | 7 | 20 | 23 | |
| 7 | 1 | Sunderland | 33 | 13 | 10 | 10 | 39 | 35 | +4 | 49 | LOLW | 17 | 8 | 6 | 3 | 20 | 13 | 16 | 5 | 4 | 7 | 19 | 22 | |
| 8 | Aston Villa | 33 | 12 | 12 | 9 | 40 | 35 | +5 | 48 | WXWW | 17 | 7 | 7 | 3 | 24 | 18 | 16 | 5 | 5 | 6 | 16 | 17 | ||
| 9 | 3 | Tottenham Hotspur | 33 | 12 | 9 | 12 | 41 | 43 | -2 | 45 | WWLW | 16 | 10 | 5 | 1 | 28 | 12 | 17 | 2 | 4 | 11 | 13 | 31 | |
| 10 | 1 | Charlton Athletic | 33 | 12 | 9 | 12 | 42 | 46 | -4 | 45 | LLWL | 16 | 10 | 4 | 2 | 26 | 11 | 17 | 2 | 5 | 10 | 16 | 35 | |
| 11 | 1 | Leicester City | 33 | 13 | 6 | 14 | 34 | 40 | -6 | 45 | LLLL | 17 | 9 | 4 | 4 | 24 | 18 | 16 | 4 | 2 | 10 | 10 | 22 | |
| 12 | 1 | Southampton | 32 | 12 | 8 | 12 | 34 | 40 | -6 | 44 | LLLW | 16 | 9 | 2 | 5 | 22 | 18 | 16 | 3 | 6 | 7 | 12 | 22 | |
| 13 | 2 | West Ham United | 33 | 9 | 12 | 12 | 40 | 43 | -3 | 39 | WXLL | 17 | 5 | 6 | 6 | 21 | 18 | 16 | 4 | 6 | 6 | 19 | 25 | |
| 14 | 1 | Newcastle United | 31 | 11 | 6 | 14 | 36 | 44 | -8 | 39 | LXLX | 14 | 7 | 2 | 5 | 19 | 15 | 17 | 4 | 4 | 9 | 17 | 29 | |
| 15 | 1 | Everton | 33 | 10 | 8 | 15 | 37 | 47 | -10 | 38 | LWWL | 16 | 5 | 7 | 4 | 23 | 21 | 17 | 5 | 1 | 11 | 14 | 26 | |
| 16 | 1 | Middlesbrough | 33 | 7 | 14 | 12 | 37 | 38 | -1 | 35 | WOLW | 16 | 3 | 7 | 6 | 15 | 18 | 17 | 4 | 7 | 6 | 22 | 20 | |
| 17 | 1 | Derby County | 33 | 8 | 11 | 14 | 32 | 54 | -22 | 35 | LLLX | 16 | 7 | 6 | 3 | 19 | 21 | 17 | 1 | 5 | 11 | 13 | 33 | |
| 18 | 1 | Manchester City | 34 | 7 | 9 | 18 | 37 | 60 | -23 | 30 | WLLL | 17 | 3 | 3 | 11 | 18 | 29 | 17 | 4 | 6 | 7 | 19 | 31 | |
| 19 | 1 | Coventry City | 33 | 7 | 9 | 17 | 33 | 56 | -23 | 30 | LWWL | 16 | 3 | 6 | 7 | 13 | 21 | 17 | 4 | 3 | 10 | 20 | 35 | |
| 20 | Bradford City | 32 | 4 | 9 | 19 | 25 | 59 | -34 | 21 | WLXX | 16 | 3 | 6 | 7 | 17 | 26 | 16 | 1 | 3 | 12 | 8 | 33 | ||
| 19 | +1 | Marcus STEWART (Ipswich Town, 2p) |
| 17 | Jimmy HASSELBAINK (Chelsea, 3p) | |
| 16 | Thierry HENRY (Arsenal, 1p) | |
| 15 | Mark VIDUKA (Leeds United) | |
| 14 | Teddy SHERINGHAM (Manchester United) | |
| 12 | Emile HESKEY (Liverpool) | |
| 11 | James BEATTIE (Southampton) | |
| Ole SOLSKJÆR (Manchester United) | ||
| Alen BOKSIC (Middlesbrough, 2p) | ||
| Jonatan JOHANSSON (Charlton Athletic) | ||
| Kevin PHILLIPS (Sunderland, 2p) | ||
| 10 | Andrew COLE (Manchester United) | |
| +1 | Gustavo POYET (Chelsea) | |
| +1 | Frédéric KANOUTÉ (West Ham United) | |
| 9 | +1 | Ade AKINBIYI (Leicester City) |
| Michael OWEN (Liverpool) | ||
| Gianfranco ZOLA (Chelsea) | ||
| Eiður GUÐJOHNSEN (Chelsea) | ||
| +1 | Paulo WANCHOPE (Manchester City) | |
| Paolo DI CANIO (West Ham United, 3p) | ||
| Les FERDINAND (Tottenham Hotspur) | ||
| Serhiy REBROV (Tottenham Hotspur, 1p) |
| Wednesday, 11 April 2001 | |||||
| 34 | Manchester City | 0-4 | Arsenal | ||
| 8 | Ljungberg | ||||
| 8 | Wiltord | ||||
| 16 | Ljungberg | ||||
| 36 | Kanu | ||||
| Friday, 13 April 2001 | |||||
| 33 | Bradford City | 2-0 | Charlton Athletic | ||
| 74(p) | Blake | ||||
| 80 | Carbone | ||||
| 33 | Liverpool | 1-2 | Leeds United | ||
| 55 | Gerrard | 4 | Ferdinand | ||
| 33 | Bowyer | ||||
| Saturday, 14 April 2001 | |||||
| 33 | Arsenal | 0-3 | Middlesbrough | ||
| 34(og) | Edu | ||||
| 38(og) | Sylvinho | ||||
| 58 | Ricard | ||||
| 33 | Aston Villa | 2-1 | Everton | ||
| 2 | Dublin | 21 | Unsworth | ||
| 81 | Taylor | ||||
| 33 | Chelsea | 1-0 | Southampton | ||
| 43 | Poyet | ||||
| 33 | Ipswich Town | 1-0 | Newcastle United | ||
| 76(p) | Stewart | ||||
| 33 | Leicester City | 1-2 | Manchester City | ||
| 41 | Akinbiyi | 17 | Goater | ||
| 67 | Wanchope | ||||
| 33 | Manchester United | 4-2 | Coventry City | ||
| 12 | Yorke | 10 | Hartson | ||
| 27 | Yorke | 33 | Hartson | ||
| 81 | Giggs | ||||
| 87 | Scholes | ||||
| 33 | Sunderland | 2-3 | Tottenham Hotspur | ||
| 3 | Kilbane | 53 | Clemence | ||
| 12 | Quinn | 75 | Doherty | ||
| 88 | Doherty | ||||
| 33 | West Ham United | 3-1 | Derby County | ||
| 5 | Kanouté | 83 | Guðjónsson | ||
| 7 | Lampard | ||||
| 45 | Cole | ||||