| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 |
| 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 307 | 783 | 2.55 | 147 | 47.88% | 86 | 28.01% | 74 | 24.10% |
| 2000/01 | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Manchester United | 31 | 21 | 7 | 3 | 68 | 21 | +47 | 70 | LWXW | 15 | 13 | 1 | 1 | 42 | 7 | 16 | 8 | 6 | 2 | 26 | 14 | ||
| 2 | Arsenal | 31 | 16 | 9 | 6 | 49 | 29 | +20 | 57 | WOWL | 16 | 13 | 3 | 0 | 39 | 8 | 15 | 3 | 6 | 6 | 10 | 21 | ||
| 3 | Ipswich Town | 31 | 16 | 4 | 11 | 47 | 36 | +11 | 52 | WWLW | 15 | 8 | 4 | 3 | 25 | 13 | 16 | 8 | 0 | 8 | 22 | 23 | ||
| 4 | 1 | Leeds United | 31 | 14 | 8 | 9 | 46 | 38 | +8 | 50 | WWXW | 15 | 7 | 3 | 5 | 23 | 19 | 16 | 7 | 5 | 4 | 23 | 19 | |
| 5 | 1 | Liverpool | 29 | 14 | 7 | 8 | 50 | 31 | +19 | 49 | WXLX | 15 | 11 | 3 | 1 | 31 | 9 | 14 | 3 | 4 | 7 | 19 | 22 | |
| 6 | 2 | Sunderland | 31 | 13 | 9 | 9 | 37 | 32 | +5 | 48 | LWXL | 16 | 8 | 6 | 2 | 18 | 10 | 15 | 5 | 3 | 7 | 19 | 22 | |
| 7 | 2 | Chelsea | 30 | 12 | 9 | 9 | 54 | 38 | +16 | 45 | WLWO | 16 | 11 | 3 | 2 | 41 | 18 | 14 | 1 | 6 | 7 | 13 | 20 | |
| 8 | 2 | Charlton Athletic | 31 | 12 | 9 | 10 | 41 | 42 | -1 | 45 | WLOX | 16 | 10 | 4 | 2 | 26 | 11 | 15 | 2 | 5 | 8 | 15 | 31 | |
| 9 | 2 | Leicester City | 31 | 13 | 6 | 12 | 32 | 35 | -3 | 45 | LLLW | 15 | 9 | 4 | 2 | 22 | 13 | 16 | 4 | 2 | 10 | 10 | 22 | |
| 10 | 2 | Aston Villa | 31 | 11 | 11 | 9 | 36 | 32 | +4 | 44 | WWOW | 15 | 6 | 6 | 3 | 20 | 15 | 16 | 5 | 5 | 6 | 16 | 17 | |
| 11 | 3 | Southampton | 30 | 12 | 8 | 10 | 34 | 37 | -3 | 44 | LWWW | 16 | 9 | 2 | 5 | 22 | 18 | 14 | 3 | 6 | 5 | 12 | 19 | |
| 12 | 1 | Tottenham Hotspur | 31 | 10 | 9 | 12 | 36 | 40 | -4 | 39 | LWLL | 15 | 9 | 5 | 1 | 26 | 11 | 16 | 1 | 4 | 11 | 10 | 29 | |
| 13 | Newcastle United | 30 | 11 | 6 | 13 | 36 | 43 | -7 | 39 | XLXL | 14 | 7 | 2 | 5 | 19 | 15 | 16 | 4 | 4 | 8 | 17 | 28 | ||
| 14 | West Ham United | 31 | 8 | 11 | 12 | 35 | 40 | -5 | 35 | LLLL | 16 | 4 | 6 | 6 | 18 | 17 | 15 | 4 | 5 | 6 | 17 | 23 | ||
| 15 | 1 | Everton | 31 | 9 | 8 | 14 | 33 | 44 | -11 | 35 | WLXL | 15 | 4 | 7 | 4 | 20 | 20 | 16 | 5 | 1 | 10 | 13 | 24 | |
| 16 | 1 | Derby County | 31 | 8 | 11 | 12 | 31 | 47 | -16 | 35 | LXWW | 15 | 7 | 6 | 2 | 19 | 17 | 16 | 1 | 5 | 10 | 12 | 30 | |
| 17 | Middlesbrough | 31 | 6 | 13 | 12 | 34 | 38 | -4 | 31 | LWOL | 15 | 3 | 6 | 6 | 15 | 18 | 16 | 3 | 7 | 6 | 19 | 20 | ||
| 18 | Manchester City | 31 | 6 | 9 | 16 | 34 | 52 | -18 | 27 | LXLW | 16 | 3 | 3 | 10 | 18 | 25 | 15 | 3 | 6 | 6 | 16 | 27 | ||
| 19 | Coventry City | 31 | 6 | 9 | 16 | 28 | 51 | -23 | 27 | WLOX | 16 | 3 | 6 | 7 | 13 | 21 | 15 | 3 | 3 | 9 | 15 | 30 | ||
| 20 | Bradford City | 30 | 3 | 9 | 18 | 22 | 57 | -35 | 18 | XXLL | 15 | 2 | 6 | 7 | 15 | 26 | 15 | 1 | 3 | 11 | 7 | 31 | ||
| 18 | +3 | Marcus STEWART (Ipswich Town, 1p) |
| 16 | +1 | Thierry HENRY (Arsenal, 1p) |
| Jimmy HASSELBAINK (Chelsea, 3p) | ||
| 15 | +1 | Mark VIDUKA (Leeds United) |
| 14 | Teddy SHERINGHAM (Manchester United) | |
| 11 | James BEATTIE (Southampton) | |
| Alen BOKSIC (Middlesbrough, 2p) | ||
| Emile HESKEY (Liverpool) | ||
| Jonatan JOHANSSON (Charlton Athletic) | ||
| Kevin PHILLIPS (Sunderland, 2p) | ||
| 10 | Ole SOLSKJÆR (Manchester United) | |
| 9 | Michael OWEN (Liverpool) | |
| Andrew COLE (Manchester United) | ||
| +1 | Eiður GUÐJOHNSEN (Chelsea) | |
| Paolo DI CANIO (West Ham United, 3p) | ||
| Les FERDINAND (Tottenham Hotspur) | ||
| Serhiy REBROV (Tottenham Hotspur, 1p) | ||
| 8 | +1 | Alan SMITH (Leeds United) |
| +1 | Gianfranco ZOLA (Chelsea) | |
| Paulo WANCHOPE (Manchester City) | ||
| David BECKHAM (Manchester United, 1p) | ||
| Don HUTCHISON (Sunderland) | ||
| Frédéric KANOUTÉ (West Ham United) |
| Saturday, 31 March 2001 | |||||
| 31 | Arsenal | 2-0 | Tottenham Hotspur | ||
| 70 | Pirès | ||||
| 87 | Henry | ||||
| 31 | Bradford City | 2-2 | Newcastle United | ||
| 8 | Wetherall | 25 | Cort | ||
| 10(p) | Blake | 77 | Acuña | ||
| 31 | Chelsea | 2-1 | Middlesbrough | ||
| 35 | Zola | 54 | Windass | ||
| 63 | Guðjohnsen | ||||
| 31 | Coventry City | 2-0 | Derby County | ||
| 44 | Hadji | ||||
| 49 | Hartson | ||||
| 31 | Liverpool | 2-0 | Manchester United | ||
| 16 | Gerrard | ||||
| 41 | Fowler | ||||
| 31 | Manchester City | 1-3 | Aston Villa | ||
| 12 | Goater | 14 | Merson | ||
| 45 | Dublin | ||||
| 65 | Hendrie | ||||
| 31 | Sunderland | 0-2 | Leeds United | ||
| 33 | Smith | ||||
| 90 | Viduka | ||||
| 31 | West Ham United | 0-2 | Everton | ||
| 45(p) | Unsworth | ||||
| 71 | Alexandersson | ||||
| Sunday, 1 April 2001 | |||||
| 31 | Charlton Athletic | 2-0 | Leicester City | ||
| 33 | Todd | ||||
| 82 | Bartlett | ||||
| Monday, 2 April 2001 | |||||
| 31 | Southampton | 0-3 | Ipswich Town | ||
| 33 | Stewart | ||||
| 68 | Stewart | ||||
| 71(p) | Stewart | ||||
| Wednesday, 4 April 2001 | |||||
| 21 | Aston Villa | 2-1 | Leicester City | ||
| 30 | Dublin | 27 | Davidson | ||
| 72 | Hendrie | ||||