| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 |
| 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 274 | 705 | 2.57 | 133 | 48.54% | 77 | 28.10% | 64 | 23.36% |
| 2000/01 | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Manchester United | 28 | 20 | 6 | 2 | 65 | 18 | +47 | 66 | WXWW | 14 | 12 | 1 | 1 | 40 | 7 | 14 | 8 | 5 | 1 | 25 | 11 | ||
| 2 | Arsenal | 28 | 14 | 8 | 6 | 44 | 29 | +15 | 50 | LWWW | 14 | 11 | 3 | 0 | 34 | 8 | 14 | 3 | 5 | 6 | 10 | 21 | ||
| 3 | Liverpool | 26 | 13 | 6 | 7 | 47 | 28 | +19 | 45 | XWXO | 13 | 10 | 2 | 1 | 28 | 8 | 13 | 3 | 4 | 6 | 19 | 20 | ||
| 4 | Sunderland | 28 | 12 | 8 | 8 | 32 | 27 | +5 | 44 | LXLL | 14 | 8 | 5 | 1 | 17 | 7 | 14 | 4 | 3 | 7 | 15 | 20 | ||
| 5 | 1 | Ipswich Town | 27 | 13 | 4 | 10 | 39 | 33 | +6 | 43 | WLLL | 14 | 7 | 4 | 3 | 22 | 12 | 13 | 6 | 0 | 7 | 17 | 21 | |
| 6 | 1 | Leeds United | 28 | 12 | 7 | 9 | 41 | 36 | +5 | 43 | WOXW | 14 | 7 | 2 | 5 | 22 | 18 | 14 | 5 | 5 | 4 | 19 | 18 | |
| 7 | 1 | Leicester City | 27 | 12 | 6 | 9 | 29 | 29 | +0 | 42 | WLWL | 14 | 8 | 4 | 2 | 20 | 13 | 13 | 4 | 2 | 7 | 9 | 16 | |
| 8 | 1 | Charlton Athletic | 28 | 11 | 8 | 9 | 38 | 40 | -2 | 41 | XWOW | 14 | 9 | 4 | 1 | 23 | 9 | 14 | 2 | 4 | 8 | 15 | 31 | |
| 9 | Chelsea | 26 | 10 | 8 | 8 | 48 | 33 | +15 | 38 | XLWW | 14 | 10 | 3 | 1 | 37 | 13 | 12 | 0 | 5 | 7 | 11 | 20 | ||
| 10 | 2 | Southampton | 27 | 10 | 8 | 9 | 32 | 34 | -2 | 38 | WWWO | 14 | 8 | 2 | 4 | 21 | 15 | 13 | 2 | 6 | 5 | 11 | 19 | |
| 11 | 1 | Newcastle United | 27 | 11 | 4 | 12 | 32 | 38 | -6 | 37 | LLLW | 13 | 7 | 2 | 4 | 18 | 13 | 14 | 4 | 2 | 8 | 14 | 25 | |
| 12 | 1 | Tottenham Hotspur | 28 | 9 | 9 | 10 | 32 | 36 | -4 | 36 | LWOO | 14 | 8 | 5 | 1 | 23 | 11 | 14 | 1 | 4 | 9 | 9 | 25 | |
| 13 | 1 | West Ham United | 27 | 8 | 11 | 8 | 35 | 32 | +3 | 35 | WXLO | 13 | 4 | 6 | 3 | 18 | 12 | 14 | 4 | 5 | 5 | 17 | 20 | |
| 14 | 1 | Aston Villa | 26 | 8 | 9 | 9 | 28 | 28 | +0 | 33 | LXWL | 12 | 4 | 5 | 3 | 16 | 13 | 14 | 4 | 4 | 6 | 12 | 15 | |
| 15 | Everton | 28 | 8 | 7 | 13 | 30 | 42 | -12 | 31 | LWXL | 14 | 4 | 6 | 4 | 19 | 19 | 14 | 4 | 1 | 9 | 11 | 23 | ||
| 16 | Derby County | 28 | 7 | 10 | 11 | 28 | 43 | -15 | 31 | WOWL | 14 | 6 | 6 | 2 | 17 | 16 | 14 | 1 | 4 | 9 | 11 | 27 | ||
| 17 | Middlesbrough | 28 | 5 | 12 | 11 | 31 | 35 | -4 | 27 | LXXX | 14 | 3 | 5 | 6 | 15 | 18 | 14 | 2 | 7 | 5 | 16 | 17 | ||
| 18 | Manchester City | 28 | 6 | 8 | 14 | 31 | 46 | -15 | 26 | WLXX | 14 | 3 | 3 | 8 | 17 | 21 | 14 | 3 | 5 | 6 | 14 | 25 | ||
| 19 | Coventry City | 28 | 5 | 8 | 15 | 26 | 48 | -22 | 23 | XXLL | 14 | 2 | 5 | 7 | 11 | 21 | 14 | 3 | 3 | 8 | 15 | 27 | ||
| 20 | Bradford City | 27 | 3 | 7 | 17 | 17 | 50 | -33 | 16 | LLLL | 13 | 2 | 4 | 7 | 11 | 22 | 14 | 1 | 3 | 10 | 6 | 28 | ||
| 15 | Marcus STEWART (Ipswich Town) | |
| +1 | Thierry HENRY (Arsenal, 1p) | |
| Jimmy HASSELBAINK (Chelsea, 3p) | ||
| 14 | +1 | Teddy SHERINGHAM (Manchester United) |
| 12 | Mark VIDUKA (Leeds United) | |
| 11 | James BEATTIE (Southampton) | |
| Emile HESKEY (Liverpool) | ||
| +1 | Jonatan JOHANSSON (Charlton Athletic) | |
| 10 | Kevin PHILLIPS (Sunderland, 2p) | |
| 9 | +1 | Ole SOLSKJÆR (Manchester United) |
| Alen BOKSIC (Middlesbrough, 2p) | ||
| Andrew COLE (Manchester United) | ||
| Paolo DI CANIO (West Ham United, 3p) | ||
| 8 | Michael OWEN (Liverpool) | |
| Paulo WANCHOPE (Manchester City) | ||
| David BECKHAM (Manchester United, 1p) | ||
| +1 | Les FERDINAND (Tottenham Hotspur) | |
| Serhiy REBROV (Tottenham Hotspur, 1p) | ||
| Frédéric KANOUTÉ (West Ham United) | ||
| 7 | Kevin CAMPBELL (Everton) | |
| +1 | Lee BOWYER (Leeds United) | |
| Gianfranco ZOLA (Chelsea) | ||
| Marians PAHARS (Southampton) | ||
| Gustavo POYET (Chelsea) |
| Saturday, 24 February 2001 | |||||
| 28 | Bradford City | 1-2 | West Ham United | ||
| 62 | Jess | 18 | Lampard | ||
| 75 | Lampard | ||||
| 28 | Coventry City | 2-2 | Charlton Athletic | ||
| 10 | Bellamy | 22 | Rufus | ||
| 67 | Hartson | 46 | Johansson | ||
| 28 | Derby County | 1-0 | Aston Villa | ||
| 42(p) | Burton | ||||
| 28 | Ipswich Town | 2-0 | Everton | ||
| 82 | Holland | ||||
| 84 | Armstrong | ||||
| 28 | Leicester City | 2-0 | Sunderland | ||
| 30 | Sturridge | ||||
| 65 | Akinbiyi | ||||
| 28 | Middlesbrough | 0-1 | Southampton | ||
| 49 | Draper | ||||
| 28 | Newcastle United | 0-1 | Manchester City | ||
| 61 | Goater | ||||
| 28 | Tottenham Hotspur | 1-2 | Leeds United | ||
| 33 | Ferdinand | 45(p) | Harte | ||
| 57 | Bowyer | ||||
| Sunday, 25 February 2001 | |||||
| 28 | Manchester United | 6-1 | Arsenal | ||
| 3 | Yorke | 16 | Henry | ||
| 18 | Yorke | ||||
| 22 | Yorke | ||||
| 26 | Keane | ||||
| 38 | Solskjær | ||||
| 90 | Sheringham | ||||