| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 |
| 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 159 | 425 | 2.67 | 78 | 49.06% | 41 | 25.79% | 40 | 25.16% |
| 2000/01 | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Manchester United | 16 | 12 | 3 | 1 | 41 | 10 | +31 | 39 | WWWW | 8 | 7 | 1 | 0 | 26 | 4 | 8 | 5 | 2 | 1 | 15 | 6 | ||
| 2 | Arsenal | 16 | 9 | 4 | 3 | 24 | 13 | +11 | 31 | WLLO | 8 | 7 | 1 | 0 | 17 | 4 | 8 | 2 | 3 | 3 | 7 | 9 | ||
| 3 | 1 | Leicester City | 16 | 8 | 5 | 3 | 17 | 12 | +5 | 29 | WLWX | 8 | 4 | 3 | 1 | 10 | 8 | 8 | 4 | 2 | 2 | 7 | 4 | |
| 4 | 1 | Liverpool | 16 | 8 | 3 | 5 | 32 | 23 | +9 | 27 | WLLW | 8 | 7 | 1 | 0 | 19 | 6 | 8 | 1 | 2 | 5 | 13 | 17 | |
| 5 | 2 | Ipswich Town | 16 | 8 | 3 | 5 | 23 | 17 | +6 | 27 | LWWW | 8 | 3 | 3 | 2 | 9 | 7 | 8 | 5 | 0 | 3 | 14 | 10 | |
| 6 | 3 | Sunderland | 16 | 7 | 5 | 4 | 17 | 16 | +1 | 26 | WWWX | 8 | 5 | 3 | 0 | 10 | 4 | 8 | 2 | 2 | 4 | 7 | 12 | |
| 7 | 4 | West Ham United | 16 | 6 | 6 | 4 | 22 | 17 | +5 | 24 | WWWW | 8 | 3 | 3 | 2 | 11 | 8 | 8 | 3 | 3 | 2 | 11 | 9 | |
| 8 | 2 | Aston Villa | 15 | 6 | 6 | 3 | 18 | 13 | +5 | 24 | XXLW | 7 | 4 | 3 | 0 | 12 | 4 | 8 | 2 | 3 | 3 | 6 | 9 | |
| 9 | 2 | Newcastle United | 16 | 7 | 3 | 6 | 18 | 16 | +2 | 24 | XWLX | 8 | 4 | 1 | 3 | 10 | 8 | 8 | 3 | 2 | 3 | 8 | 8 | |
| 10 | 2 | Tottenham Hotspur | 16 | 7 | 2 | 7 | 22 | 23 | -1 | 23 | LWWL | 8 | 7 | 1 | 0 | 17 | 6 | 8 | 0 | 1 | 7 | 5 | 17 | |
| 11 | 1 | Leeds United | 15 | 6 | 4 | 5 | 22 | 22 | +0 | 22 | LWLX | 8 | 5 | 0 | 3 | 16 | 12 | 7 | 1 | 4 | 2 | 6 | 10 | |
| 12 | Charlton Athletic | 16 | 6 | 3 | 7 | 21 | 24 | -3 | 21 | LLWL | 8 | 5 | 2 | 1 | 13 | 4 | 8 | 1 | 1 | 6 | 8 | 20 | ||
| 13 | Everton | 16 | 6 | 3 | 7 | 19 | 23 | -4 | 21 | LWWW | 8 | 3 | 2 | 3 | 11 | 11 | 8 | 3 | 1 | 4 | 8 | 12 | ||
| 14 | Chelsea | 16 | 5 | 5 | 6 | 28 | 23 | +5 | 20 | WLLX | 8 | 5 | 2 | 1 | 21 | 9 | 8 | 0 | 3 | 5 | 7 | 14 | ||
| 15 | Southampton | 16 | 4 | 5 | 7 | 21 | 28 | -7 | 17 | LLWX | 8 | 3 | 1 | 4 | 14 | 15 | 8 | 1 | 4 | 3 | 7 | 13 | ||
| 16 | Manchester City | 16 | 4 | 2 | 10 | 18 | 30 | -12 | 14 | LLLL | 8 | 2 | 1 | 5 | 10 | 11 | 8 | 2 | 1 | 5 | 8 | 19 | ||
| 17 | 2 | Derby County | 16 | 2 | 7 | 7 | 19 | 31 | -12 | 13 | WLWO | 8 | 1 | 5 | 2 | 10 | 15 | 8 | 1 | 2 | 5 | 9 | 16 | |
| 18 | 1 | Coventry City | 16 | 3 | 3 | 10 | 15 | 32 | -17 | 12 | LXLL | 8 | 1 | 2 | 5 | 5 | 13 | 8 | 2 | 1 | 5 | 10 | 19 | |
| 19 | 1 | Middlesbrough | 16 | 2 | 5 | 9 | 19 | 27 | -8 | 11 | LXLL | 8 | 0 | 3 | 5 | 7 | 15 | 8 | 2 | 2 | 4 | 12 | 12 | |
| 20 | Bradford City | 16 | 2 | 5 | 9 | 9 | 25 | -16 | 11 | WXLL | 8 | 2 | 3 | 3 | 6 | 7 | 8 | 0 | 2 | 6 | 3 | 18 | ||
| 11 | Teddy SHERINGHAM (Manchester United) | |
| +1 | Mark VIDUKA (Leeds United) | |
| +1 | Jimmy HASSELBAINK (Chelsea, 3p) | |
| 10 | +1 | Emile HESKEY (Liverpool) |
| 9 | Marcus STEWART (Ipswich Town) | |
| Thierry HENRY (Arsenal, 1p) | ||
| 7 | Michael OWEN (Liverpool) | |
| David BECKHAM (Manchester United) | ||
| +1 | Paolo DI CANIO (West Ham United, 3p) | |
| 6 | James BEATTIE (Southampton) | |
| Alan SMITH (Leeds United) | ||
| Andrew COLE (Manchester United) | ||
| Marians PAHARS (Southampton) | ||
| Jonatan JOHANSSON (Charlton Athletic) | ||
| Les FERDINAND (Tottenham Hotspur) | ||
| 5 | Malcolm CHRISTIE (Derby County) | |
| Alen BOKSIC (Middlesbrough, 1p) | ||
| +1 | Gianfranco ZOLA (Chelsea) | |
| Alan SHEARER (Newcastle United, 2p) | ||
| Paulo WANCHOPE (Manchester City) | ||
| +1 | Kevin PHILLIPS (Sunderland, 1p) | |
| Serhiy REBROV (Tottenham Hotspur, 1p) | ||
| Francis JEFFERS (Everton) |
| Saturday, 2 December 2000 | |||||
| 16 | Arsenal | 1-0 | Southampton | ||
| 85 | Vieira | ||||
| 16 | Aston Villa | 1-1 | Newcastle United | ||
| 4 | Dublin | 82 | Solano | ||
| 16 | Bradford City | 2-1 | Coventry City | ||
| 80 | Collymore | 64 | Aloisi | ||
| 83 | Beagrie | ||||
| 16 | Ipswich Town | 0-1 | Derby County | ||
| 28 | Delap | ||||
| 16 | Leicester City | 3-1 | Leeds United | ||
| 8 | Savage | 75 | Viduka | ||
| 17 | Akinbiyi | ||||
| 29 | Taggart | ||||
| 16 | Liverpool | 3-0 | Charlton Athletic | ||
| 5(og) | Fish | ||||
| 78 | Heskey | ||||
| 90 | Babbel | ||||
| 16 | Manchester United | 2-0 | Tottenham Hotspur | ||
| 40 | Scholes | ||||
| 84 | Solskjær | ||||
| 16 | West Ham United | 1-0 | Middlesbrough | ||
| 44 | Di Canio | ||||
| Sunday, 3 December 2000 | |||||
| 16 | Chelsea | 2-1 | Manchester City | ||
| 27 | Zola | 81 | Dickov | ||
| 43 | Hasselbaink | ||||
| Monday, 4 December 2000 | |||||
| 16 | Sunderland | 2-0 | Everton | ||
| 45 | Rae | ||||
| 65 | Phillips | ||||