Results| Tuesday, 23 August 2011 |
| r2l2 |  Botafogo | 1-0 | Atlético-MG | 3-1 |
| 45 | Herrera |
| |
|
| Wednesday, 24 August 2011 |
| r2l2 | São Paulo | 3-0 | Ceará | 4-2 |
| 55 | Cícero |
| |
|
| 61 | Lucas Moura |
| |
|
| 64 | Dagoberto |
| |
|
| r2l2 | Athlético-PR | 0-1 | Flamengo | 0-2 |
| |
| 73 | Ronaldinho |
|
| Thursday, 25 August 2011 |
| r2l2 | Palmeiras | 3-1 | Vasco da Gama | 3-3 |
| 12 | Luan |
| 57 | Jumar |
|
| 53 | Kléber Gladiador |
| |
|
| 90 | Marcos Assunçao |
| |
|
| Tuesday, 6 September 2011 |
| r2l2 |  Estudiantes (LP) | 1-0 | Arsenal | 1-2 |
| 62 | Sánchez |
| |
|
| Wednesday, 7 September 2011 |
| r2l2 | Godoy Cruz | 0-0 | Lanús | 2-2 |
| Thursday, 8 September 2011 |
| r2l2 | Vélez Sársfield | 4-0 | Argentinos Juniors | 4-0 |
| 23 | Franco |
| |
|
| 55 | Fernández |
| |
|
| 74(p) | Martínez |
| |
|
| 84 | Canteros |
| |
|
| Wednesday, 14 September 2011 |
| r2l2 |  Deportes Iquique | 0-0 | Universidad Católica | 1-2 |
| r2l2 |  Universitario | 2-0 | Anzoátegui* | 4-1 |
| 73 | Ruidíaz |
| |
|
| 80 | Vitti |
| |
|
| Tuesday, 20 September 2011 |
| r2l2 |  Emelec | 1-2 | Olimpia | 2-4 |
| 72 | Franco |
| 6 | Ortiz |
|
| |
| 25 | Zeballos |
|
Abandoned after 80 minutes.
|
| r2l2 |  Aurora | 5-2 | Nacional | 6-3 |
| 21 | Reinoso |
| 7 | Teixeira |
|
| 26(p) | Peña |
| 32 | Teixeira |
|
| 39 | Sanjurjo |
| |
|
| 74 | Andaveris |
| |
|
| 90 | Cardozo |
| |
|
| Wednesday, 21 September 2011 |
| r2l2 |  Nacional | 0-2 | Universidad de Chile | 0-3 |
| |
| 11 | Vargas |
|
| |
| 12 | Rodríguez |
|
Abandoned after 47 minutes.
|
| r2l2 | Libertad | 1-0 | La Equidad | 2-0 |
| 18 | Canuto |
| |
|
| Thursday, 22 September 2011 |
| r2l2 | Trujillanos | 0-1 | LDU Quito | 1-5 |
| |
| 30 | Bolaños |
|
| r2l2 | Cali | 1-1 | Santa Fé | 2-2, aet, p5-6 |
| 14(og) | Roa |
| 67 | Galván |
|
