Results| Wednesday, 10 August 2011 |
| r2l1 |  Atlético-MG | 1-2 | Botafogo |
|
| r2l1 | Flamengo | 1-0 | Athlético-PR |
|
| r2l1 | Ceará | 2-1 | São Paulo |
|
| Thursday, 11 August 2011 |
| r2l1 | Vasco da Gama | 2-0 | Palmeiras |
|
| Tuesday, 23 August 2011 |
| r2l2 | Botafogo | 1-0 | Atlético-MG | 3-1 |
| Wednesday, 24 August 2011 |
| r2l2 | São Paulo | 3-0 | Ceará | 4-2 |
| r2l2 | Athlético-PR | 0-1 | Flamengo | 0-2 |
| Thursday, 25 August 2011 |
| r2l2 | Palmeiras | 3-1 | Vasco da Gama | 3-3 |
| Tuesday, 30 August 2011 |
| r2l1 |  Arsenal | 2-0 | Estudiantes (LP) |
|
| r2l1 |  Nacional | 1-1 | Aurora |
|
| Wednesday, 31 August 2011 |
| r2l1 | Lanús | 2-2 | Godoy Cruz |
|
| Thursday, 1 September 2011 |
| r2l1 | Argentinos Juniors | 0-0 | Vélez Sársfield |
|
| r2l1 |  Anzoátegui* | 1-2 | Universitario |
|
| Tuesday, 6 September 2011 |
| r2l2 | Estudiantes (LP) | 1-0 | Arsenal | 1-2 |
| Wednesday, 7 September 2011 |
| r2l2 | Godoy Cruz | 0-0 | Lanús | 2-2 |
| Thursday, 8 September 2011 |
| r2l1 |  Universidad Católica | 2-1 | Deportes Iquique |
|
| r2l2 | Vélez Sársfield | 4-0 | Argentinos Juniors | 4-0 |
| Tuesday, 13 September 2011 |
| r2l1 | Universidad de Chile | 1-0 | Nacional |
|
| r2l1 |  LDU Quito | 4-1 | Trujillanos |
|
| r2l1 |  La Equidad | 0-1 | Libertad |
|
| Wednesday, 14 September 2011 |
| r2l2 | Deportes Iquique | 0-0 | Universidad Católica | 1-2 |
| r2l2 | Universitario | 2-0 | Anzoátegui* | 4-1 |
| Thursday, 15 September 2011 |
| r2l1 | Santa Fé | 1-1 | Cali |
|
| r2l1 | Olimpia | 2-1 | Emelec |
|
| Tuesday, 20 September 2011 |
| r2l2 | Emelec | 1-2 | Olimpia | 2-4 |
Abandoned after 80 minutes.
Score awarded as 1-2. |
| r2l2 | Aurora | 5-2 | Nacional | 6-3 |
| Wednesday, 21 September 2011 |
| r2l2 | Nacional | 0-2 | Universidad de Chile | 0-3 |
Abandoned after 47 minutes.
Score awarded as 0-2. |
| r2l2 | Libertad | 1-0 | La Equidad | 2-0 |
| Thursday, 22 September 2011 |
| r2l2 | Trujillanos | 0-1 | LDU Quito | 1-5 |
| r2l2 | Cali | 1-1 | Santa Fé | 2-2, aet, p5-6 |
