| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 320 | 846 | 2.64 | 165 | 51.56% | 76 | 23.75% | 79 | 24.69% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Sporting Kansas City | 34 | 18 | 9 | 7 | 42 | 27 | +15 | 63 | WOXW | 17 | 10 | 4 | 3 | 22 | 12 | 17 | 8 | 5 | 4 | 20 | 15 | ||
| 2 | D.C. United | 34 | 17 | 7 | 10 | 53 | 43 | +10 | 58 | XWWX | 17 | 12 | 4 | 1 | 37 | 17 | 17 | 5 | 3 | 9 | 16 | 26 | ||
| 3 | 1 | New York Red Bulls | 34 | 16 | 9 | 9 | 57 | 46 | +11 | 57 | WOLW | 17 | 11 | 4 | 2 | 34 | 18 | 17 | 5 | 5 | 7 | 23 | 28 | |
| 4 | 1 | Chicago Fire | 34 | 17 | 6 | 11 | 46 | 41 | +5 | 57 | XLWL | 17 | 11 | 3 | 3 | 27 | 18 | 17 | 6 | 3 | 8 | 19 | 23 | |
| 5 | Houston Dynamo | 34 | 14 | 11 | 9 | 48 | 41 | +7 | 53 | LWXW | 17 | 11 | 6 | 0 | 31 | 12 | 17 | 3 | 5 | 9 | 17 | 29 | ||
| 6 | Columbus Crew | 33 | 14 | 7 | 12 | 42 | 43 | -1 | 49 | LXWL | 16 | 10 | 3 | 3 | 26 | 20 | 17 | 4 | 4 | 9 | 16 | 23 | ||
| 7 | Montréal Impact | 34 | 12 | 6 | 16 | 45 | 51 | -6 | 42 | LOXO | 17 | 10 | 3 | 4 | 31 | 19 | 17 | 2 | 3 | 12 | 14 | 32 | ||
| 8 | Philadelphia Union | 34 | 10 | 6 | 18 | 37 | 45 | -8 | 36 | LLLW | 17 | 7 | 2 | 8 | 22 | 20 | 17 | 3 | 4 | 10 | 15 | 25 | ||
| 9 | New England Revolution | 34 | 9 | 8 | 17 | 39 | 44 | -5 | 35 | WWLL | 17 | 7 | 6 | 4 | 23 | 15 | 17 | 2 | 2 | 13 | 16 | 29 | ||
| 10 | Toronto FC | 33 | 5 | 8 | 20 | 35 | 60 | -25 | 23 | OLLL | 17 | 3 | 5 | 9 | 15 | 25 | 16 | 2 | 3 | 11 | 20 | 35 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | San Jose Earthquakes | 34 | 19 | 9 | 6 | 72 | 43 | +29 | 66 | XXWX | 17 | 10 | 6 | 1 | 43 | 22 | 17 | 9 | 3 | 5 | 29 | 21 | ||
| 2 | Real Salt Lake | 34 | 17 | 6 | 11 | 46 | 35 | +11 | 57 | OOWW | 17 | 11 | 2 | 4 | 27 | 15 | 17 | 6 | 4 | 7 | 19 | 20 | ||
| 3 | Seattle Sounders | 33 | 15 | 11 | 7 | 51 | 32 | +19 | 56 | WOWO | 17 | 11 | 2 | 4 | 27 | 11 | 16 | 4 | 9 | 3 | 24 | 21 | ||
| 4 | LA Galaxy | 33 | 15 | 6 | 12 | 58 | 47 | +11 | 51 | XLXW | 16 | 9 | 1 | 6 | 30 | 20 | 17 | 6 | 5 | 6 | 28 | 27 | ||
| 5 | Vancouver Whitecaps | 34 | 11 | 10 | 13 | 35 | 41 | -6 | 43 | OLWO | 17 | 8 | 6 | 3 | 25 | 17 | 17 | 3 | 4 | 10 | 10 | 24 | ||
| 6 | FC Dallas | 33 | 9 | 11 | 13 | 40 | 45 | -5 | 38 | LXXW | 16 | 6 | 7 | 3 | 19 | 14 | 17 | 3 | 4 | 10 | 21 | 31 | ||
| 7 | Colorado Rapids | 34 | 11 | 4 | 19 | 44 | 50 | -6 | 37 | WWLX | 17 | 8 | 3 | 6 | 29 | 19 | 17 | 3 | 1 | 13 | 15 | 31 | ||
| 8 | Portland Timbers | 34 | 8 | 10 | 16 | 34 | 56 | -22 | 34 | XWLX | 17 | 7 | 6 | 4 | 24 | 21 | 17 | 1 | 4 | 12 | 10 | 35 | ||
| 9 | Chivas USA | 33 | 7 | 8 | 18 | 22 | 56 | -34 | 29 | LXLL | 17 | 3 | 3 | 11 | 9 | 30 | 16 | 4 | 5 | 7 | 13 | 26 | ||
| 27 | +2 | Chris WONDOLOWSKI (San Jose Earthquakes) |
| 18 | +2 | Kenny COOPER (New York Red Bulls) |
| 17 | Álvaro SABORIO (Real Salt Lake) | |
| 16 | +1 | Robbie KEANE (LA Galaxy) |
| 15 | +1 | Thierry HENRY (New York Red Bulls) |
| 14 | Eddie JOHNSON (Seattle Sounders) | |
| 13 | Fredy MONTERO (Seattle Sounders) | |
| Alan GORDON (San Jose Earthquakes) | ||
| 12 | Chris PONTIUS (D.C. United) | |
| Will BRUIN (Houston Dynamo) | ||
| 11 | Kei KAMARA (Sporting Kansas City) | |
| Saër SÈNE (New England Revolution) | ||
| 10 | Steven LENHART (San Jose Earthquakes) | |
| 9 | Landon DONOVAN (LA Galaxy) | |
| +1 | Blas PÉREZ (FC Dallas) | |
| Eddie GAVEN (Columbus Crew) | ||
| Edgar ESPÍNDOLA (Real Salt Lake) | ||
| Jairo ARRIETA (Columbus Crew) | ||
| Danny KOEVERMANS (Toronto FC) | ||
| +1 | C.J. SAPONG (Sporting Kansas City) | |
| Patrice BERNIER (Montréal Impact) |
| Sunday, 21 October 2012 | |||||
| San Jose Earthquakes | 2-2 | LA Galaxy | |||
| 61 | Chávez | 59 | Keane | ||
| 73 | Wondolowski | 69 | Buddle | ||
| Vancouver Whitecaps | 0-1 | Portland Timbers | |||
| 39 | Jewsbury | ||||
| Seattle Sounders | 3-1 | FC Dallas | |||
| 32 | Evans | 40 | Pérez | ||
| 60 | Evans | ||||
| 79 | Rosales | ||||
| Wednesday, 24 October 2012 | |||||
| Sporting Kansas City | 2-1 | Philadelphia Union | |||
| 40 | Peterson | 53 | Hoppenot | ||
| 82 | Sapong | ||||
| Saturday, 27 October 2012 | |||||
| Real Salt Lake | 0-0 | Vancouver Whitecaps | |||
| Philadelphia Union | 0-3 | New York Red Bulls | |||
| 13 | Cooper | ||||
| 35 | Henry | ||||
| 66 | Cooper | ||||
| Montréal Impact | 0-1 | New England Revolution | |||
| 88 | Soares | ||||
| Colorado Rapids | 2-0 | Houston Dynamo | |||
| 9 | Hill | ||||
| 76 | Akpan | ||||
| Chicago Fire | 1-1 | D.C. United | |||
| 16 | Nyarko | 50 | Pajoy | ||
| Portland Timbers | 1-1 | San Jose Earthquakes | |||
| 67 | Dike | 24 | Wondolowski | ||