| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 |
| 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 192 | 551 | 2.86 | 92 | 47.92% | 44 | 22.92% | 56 | 29.17% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 32 | 17 | 8 | 7 | 55 | 37 | +18 | 59 | WXLW | 16 | 11 | 3 | 2 | 28 | 13 | 16 | 6 | 5 | 5 | 27 | 24 | ||
| 2 | D.C. United | 32 | 16 | 6 | 10 | 58 | 37 | +21 | 54 | XLWW | 16 | 9 | 2 | 5 | 37 | 22 | 16 | 7 | 4 | 5 | 21 | 15 | ||
| 3 | Chicago Fire | 32 | 15 | 4 | 13 | 49 | 50 | -1 | 49 | LLXW | 16 | 8 | 3 | 5 | 30 | 27 | 16 | 7 | 1 | 8 | 19 | 23 | ||
| 4 | 1 | Metrostars | 32 | 12 | 11 | 9 | 53 | 49 | +4 | 47 | WWXL | 16 | 6 | 7 | 3 | 28 | 27 | 16 | 6 | 4 | 6 | 25 | 22 | |
| 5 | 1 | Kansas City Wizards | 32 | 11 | 12 | 9 | 52 | 44 | +8 | 45 | XXLL | 16 | 6 | 6 | 4 | 23 | 18 | 16 | 5 | 6 | 5 | 29 | 26 | |
| 6 | Columbus Crew | 32 | 11 | 5 | 16 | 34 | 45 | -11 | 38 | XWLL | 16 | 7 | 1 | 8 | 15 | 19 | 16 | 4 | 4 | 8 | 19 | 26 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | San Jose Earthquakes | 32 | 18 | 10 | 4 | 53 | 31 | +22 | 64 | WXWX | 16 | 9 | 7 | 0 | 30 | 14 | 16 | 9 | 3 | 4 | 23 | 17 | ||
| 2 | Dallas Burn | 32 | 13 | 9 | 10 | 52 | 44 | +8 | 48 | XOWL | 16 | 8 | 5 | 3 | 28 | 20 | 16 | 5 | 4 | 7 | 24 | 24 | ||
| 3 | 1 | Colorado Rapids | 32 | 13 | 6 | 13 | 40 | 37 | +3 | 45 | WOXW | 16 | 10 | 2 | 4 | 24 | 14 | 16 | 3 | 4 | 9 | 16 | 23 | |
| 4 | 1 | LA Galaxy | 32 | 13 | 6 | 13 | 44 | 45 | -1 | 45 | LWWL | 16 | 10 | 3 | 3 | 29 | 17 | 16 | 3 | 3 | 10 | 15 | 28 | |
| 5 | Real Salt Lake | 32 | 5 | 5 | 22 | 30 | 65 | -35 | 20 | LXLL | 16 | 5 | 3 | 8 | 19 | 24 | 16 | 0 | 2 | 14 | 11 | 41 | ||
| 6 | Chivas USA | 32 | 4 | 6 | 22 | 31 | 67 | -36 | 18 | LXWL | 16 | 3 | 2 | 11 | 15 | 30 | 16 | 1 | 4 | 11 | 16 | 37 | ||
| Saturday, 15 October 2005 | |||||
| New England Revolution | 1-0 | Chicago Fire | |||
| Dallas Burn | 2-2 | Kansas City Wizards | |||
| LA Galaxy | 1-3 | San Jose Earthquakes | |||
| D.C. United | 2-2 | Columbus Crew | |||
| Sunday, 16 October 2005 | |||||
| Chivas USA | 0-2 | Metrostars | |||
| 17 | +1 | Taylor TWELLMAN (New England Revolution) |
| 16 | +1 | Jaime MORENO (D.C. United, 9p) |
| 12 | +1 | Landon DONOVAN (LA Galaxy, 4p) |
| Jeff CUNNINGHAM (Colorado Rapids, 2p) | ||
| 11 | +1 | Amado GUEVARA (Metrostars, 4p) |
| Herculez GOMEZ (LA Galaxy) | ||
| Christian GÓMEZ (D.C. United) | ||
| Carlos RUIZ (Dallas Burn, 3p) | ||
| 10 | Clint DEMPSEY (New England Revolution) | |
| Youri DJORKAEFF (Metrostars, 2p) | ||
| Josh WOLFF (Kansas City Wizards, 1p) | ||
| 9 | +1 | Dwayne DE ROSARIO (San Jose Earthquakes, 1p) |
| +2 | Edson BUDDLE (Columbus Crew) | |
| Jason KREIS (Real Salt Lake, 3p) | ||
| Scott SEALY (Kansas City Wizards) | ||
| 8 | Nate JAQUA (Chicago Fire) | |
| Chris ROLFE (Chicago Fire) | ||
| Alejandro MORENO (San Jose Earthquakes) | ||
| Eddie GAVEN (Metrostars) | ||
| Pat NOONAN (New England Revolution) | ||
| 7 | Sergio GALVÁN (Metrostars) | |
| Ante RAZOV (Metrostars) | ||
| Jean-Philippe PEGUERO (Colorado Rapids, 1p) | ||
| Sasha VICTORINE (Kansas City Wizards) | ||
| Chris KLEIN (Kansas City Wizards) | ||
| Brian CHING (San Jose Earthquakes) | ||
| Roberto MINA (Dallas Burn) | ||
| +1 | Mark CHUNG (San Jose Earthquakes) |